Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies.
TL;DR: Interestingly, several observations indicate that the calibrated assumption of correct doses of vitamins such as folic acid,itamin B6, vitamin B12, and betaine may control HHCys-related conditions.
read more
Abstract: Hyperhomocysteinemia is recognized as a risk factor for several diseases, including cardiovascular and neurological conditions. Homocysteine (HCys) is a key metabolite involved in the biosynthesis and metabolism of methionine (Met), which plays a pivotal role in the physiological cell's life cycle. The biochemistry of Met is finely regulated by several enzymes that control HCys concentration. Indeed, balanced activity among the enzymes is essential for the cell's well-being, while its malfunction could raise HCys concentration which can lead to the onset of several pathological conditions. The HCys concentration increase seems to be caused mainly by the widely diffused polymorphisms of several enzymes. Nowadays, a blood test can easily detect elevated concentrations of HCys, referred to as Hyperhomocysteinemia (HHCys). Prolonged exposure to this condition can lead to the onset of cardiovascular disease and can lead to the development of atherosclerosis, stroke, inflammatory syndromes like osteoporosis and rheumatism, as well as neuronal pathologies including Alzheimer's and Parkinson's diseases. In this review, we analyzed the literature of several pathological conditions in which the molecular pathways of HHCys are involved. Interestingly, several observations indicate that the calibrated assumption of correct doses of vitamins such as folic acid, vitamin B6, vitamin B12, and betaine may control HHCys-related conditions.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The synthesis of fibroblast growth factor 23 is upregulated by homocysteine in UMR106 osteoblast-like cells
TL;DR: In this paper , the effect of homocysteine on FGF23 was investigated in UMR-106 osteoblast-like cells, and the effect was shown to be at least in part mediated by oxidative stress.
3
The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders.
Gerwyn Morris,Basant K. Puri,Chiara C. Bortolasci,André F. Carvalho,Michael Berk,Ken Walder,Estefania G. Moreira,Michael Maes +7 more
TL;DR: In this article, the pathways mediating the anti-inflammatory effects of HDL, ApoA1, and PON1 were discussed and the mechanisms leading to compromised HDL and Paroxonase (PON) levels and function in an environment of chronic inflammation.
2
Methionine and cysteine oxidation are regulated in a dose dependent manner by dietary Cys intake in neonatal piglets receiving enteral nutrition
Anna K. Shoveller,Julia Guazzelli Pezzali,James D. House,Robert F. Bertolo,Paul B. Pencharz,Ronald O. Ball +5 more
TL;DR: Increasing dietary levels of Cys resulted in a reduction in Met oxidation until the requirement for the total sulfur AA was met, indicating the sparing capacity by Cys of Met occurs through inhibition of the transsulfuration pathway in neonatal piglets.
Voluntary Exercise Attenuates Hyperhomocysteinemia, But Does not Protect Against Hyperhomocysteinemia-Induced Testicular and Epididymal Disturbances
Dayane Priscila dos Santos,Diogo Farias Ribeiro,Giovanna Fachetti Frigoli,Rafaela Pires Erthal,Suellen Ribeiro da Silva Scarton,Gláucia Eloisa Munhoz de Lion Siervo,Fábio Rodrigues Ferreira Seiva,Larissa Staurengo-Ferrari,Waldiceu A. Verri,Rafael Deminice,Glaura Scantamburlo Alves Fernandes +10 more
TL;DR: In this paper, the effect of hyperhomocysteinemia (HHcy) on testis, epididymis and sperm quality was investigated in Swiss mice with and without physical exercise.
2
References
Systematic review and meta-analysis
TL;DR: In this review the usual methods applied in systematic reviews and meta-analyses are outlined, and the most common procedures for combining studies with binary outcomes are described, illustrating how they can be done using Stata commands.
34.9K
Meta-Analysis: A Constantly Evolving Research Integration Tool
TL;DR: The four articles in this special section onMeta-analysis illustrate some of the complexities entailed in meta-analysis methods and contributes both to advancing this methodology and to the increasing complexities that can befuddle researchers.
20.8K
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
TL;DR: The longitudinal glomerular filtration rate was estimated among 1,120,295 adults within a large, integrated system of health care delivery in whom serum creatinine had been measured between 1996 and 2000 and who had not undergone dialysis or kidney transplantation.
10.6K
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
TL;DR: In this paper, the longitudinal glomerular filtration rate (GFR) among 1,120,295 adults within a large, integrated system of health care delivery in whom serum creatinine had been measured between 1996 and 2000 and who had not undergone dialysis or kidney transplantation.
7.5K