Hyperbaric Oxygen Boosts PD-1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors.
Xin Liu,Ningbing Ye,Sha Liu,Jiankun Guan,Qingyuan Deng,Zhijie Zhang,Chen Xiao,Zeyang Ding,Bixiang Zhang,Xiaoping Chen,Zifu Li,Xiangliang Yang +11 more
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TL;DR: In this article, the authors leveraged hyperbaric oxygen (HBO) for the first time to address the two key factors that limit the antitumor efficacy of T cell immune checkpoint blockade inhibitors, e.g., programmed cell death-1 antibody (PD-1 Ab), against solid tumors.
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Abstract: Aberrant mechanical properties and immunosuppression are the two key factors that limit the antitumor efficacy of T cell immune checkpoint blockade inhibitors, e.g., programmed cell death-1 antibody (PD-1 Ab), against solid tumors in the clinic. This study leverages hyperbaric oxygen (HBO) for the first time to address these two issues and reports the PD-1-Ab-mediated immune responses against various stroma-rich solid malignancies. The results demonstrate that HBO promoted PD-1 Ab delivery and T cells infiltration into tumor parenchyma by depleting the extracellular matrix's main components, such as collagen and fibronectin. Furthermore, HBO disrupts hypoxia-mediated immunosuppression and helps PD-1 Ab trigger robust cytotoxic T lymphocytes and long-lasting immunological memory to inhibit tumor relapses. Such enhanced immune responses are effective in solid tumors from rodents and the cancer cells from hepatocellular carcinoma patients. The results illustrate that HBO bolsters antitumor efficacy of PD-1 Ab, and the HBO-PD-1 Ab combination is a promising stroma-rich solid tumors' treatment in the clinic.
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Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors.
Yukun Huang,Yu Chen,Songlei Zhou,Liang Chen,Jiahao Wang,Yuanyuan Pei,Minjun Xu,Jingxian Feng,Tianze Jiang,Kaifan Liang,Shanshan Liu,Qingxiang Song,Gan Jiang,Xiao Gu,Qian Zhang,Xiaoling Gao,Jun Chen +16 more
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Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy.
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Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells.
TL;DR: The results collectively reveal that the combination of HBO with Doxil is an effective and safe treatment modality and could quickly translate to clinical trials for patients with hypoxic solid tumors.
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