Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.
Avisek Majumder,Mahavir Singh,Jyotirmaya Behera,Nicholas T. Theilen,Akash K. George,Neetu Tyagi,Naira Metreveli,Suresh C. Tyagi +7 more
TL;DR: Evidence is provided that NaHS is beneficial in mitigating HHcy-mediated skeletal injury incited by oxidative/ER stress responses, and functional studies revealed that Na HS administration improved muscle fatigability in CBS+/- mice.
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Abstract: Although hyperhomocysteinemia (HHcy) occurs because of the deficiency in cystathionine-β-synthase (CBS) causing skeletal muscle dysfunction, it is still unclear whether this effect is mediated thro...
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Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs.
TL;DR: A wide array of significant roles of H2S in the physiological regulation of all organ functions emerges from this review.
231
From endoplasmic reticulum stress to the inflammatory response.
Randal J. Kaufman
- 01 Jan 2010
TL;DR: Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response as mentioned in this paper.
68
Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation.
TL;DR: It is observed that CSE deficiency alters the expressions of ferroptosis and lipid peroxidation-related proteins and enhances global protein acetylation in mouse skeletal muscles under aging or injury conditions.
54
Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production.
TL;DR: In this article, the authors established a broilers model of H2S exposure for 42 days to assess pyroptosis and obtain a ceRNA network by immunohistochemistry and RNA sequencing, and verified circRNA-IGLL1-17828/miR-6631-5p/DUSP6 axis by double luciferase reporter assay.
49
Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis.
Yanjie Zhang,Yanjie Zhang,Yuehong Wang,Ethan Read,Ming Fu,Ming Fu,Yanxi Pei,Lingyun Wu,Lingyun Wu,Rui Wang,Guangdong Yang +10 more
TL;DR: The activation of CSE/H2S pathway and decrease of intracellular Ca2+ are two cellular protective mechanisms against Golgi stress, and CSE or H2S system would be a target for preventing skeletal muscle dysfunctions.
47
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