Journal Article10.1089/ARS.2006.8.243
Hydrogen peroxide: a signaling messenger.
James R. Stone,Suping Yang +1 more
1.1K
TL;DR: This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2 O2 and identifies oxidation-dependent steps in signal transduction pathways being uncovered.
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Abstract: Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays important roles in host defense and oxidative biosynthetic reactions. In addition there is growing evidence that at low levels, H2O2 also functions as a signaling agent, particularly in higher organisms. This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2O2. All aerobic organisms studied to date from prokaryotes to humans appear to tightly regulate their intracellular H2O2 concentrations at relatively similar levels. Multiple biochemical strategies for rapidly reacting with these low endogenous levels of H2O2 have been elucidated from the study of peroxidases and catalases. Welldefined biochemical pathways involved in the response to exogenous H2O2 have been described in both prokaryotes and yeast. In animals and plants, regulated enzymatic systems for generating H2O2 have been described. In addition oxidation-dependent steps in ...
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Redox regulation of macrophage migration inhibitory factor expression in rat neurons.
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Gpx3-dependent Responses Against Oxidative Stress in Saccharomyces cerevisiae
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TL;DR: In this article, the function of the Gpx3 protein in an adaptive response against oxidative stress was investigated in wild-type, gpx3-deletion mutant, and gpx 3-defection mutant overexpressing Gpx 3 protein strains, and it was suggested that the regulation of genes related to the capacity to detoxify oxidants and repair oxidative stress-induced damages affected by Yap1 as well as metabolism and protein fate independent from Yap 1.
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In vivo characterisation of a catalase-based biosensor for real-time electrochemical monitoring of brain hydrogen peroxide in freely-moving animals
TL;DR: The enzymatic component of the paired H2O2 sensor was found to be stable over a continuous monitoring period of 12 days, thereby demonstrating the suitability of this sensor for the long-term chronic detection of brain H 2O2.
Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response.
Sarah J. Quillin,Adam J. Hockenberry,Michael C. Jewett,H. Steven Seifert +3 more
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Klaus Apel,Heribert Hirt +1 more
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