Journal Article10.1089/ARS.2006.8.243
Hydrogen peroxide: a signaling messenger.
James R. Stone,Suping Yang +1 more
1.1K
TL;DR: This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2 O2 and identifies oxidation-dependent steps in signal transduction pathways being uncovered.
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Abstract: Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays important roles in host defense and oxidative biosynthetic reactions. In addition there is growing evidence that at low levels, H2O2 also functions as a signaling agent, particularly in higher organisms. This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2O2. All aerobic organisms studied to date from prokaryotes to humans appear to tightly regulate their intracellular H2O2 concentrations at relatively similar levels. Multiple biochemical strategies for rapidly reacting with these low endogenous levels of H2O2 have been elucidated from the study of peroxidases and catalases. Welldefined biochemical pathways involved in the response to exogenous H2O2 have been described in both prokaryotes and yeast. In animals and plants, regulated enzymatic systems for generating H2O2 have been described. In addition oxidation-dependent steps in ...
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A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
TL;DR: It is revealed that the sub-toxic and toxic levels of H2O2 indeed induced pseudohyphae, but not true hyphae and that the Cek1-mediated signaling pathway is not solely responsible for pseudohYphal formation by subtoxic H2 O2 and, but instead, complex networking pathway may exists by the activation of different regulators.
References
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