Journal Article10.1089/ARS.2006.8.243
Hydrogen peroxide: a signaling messenger.
James R. Stone,Suping Yang +1 more
1.1K
TL;DR: This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2 O2 and identifies oxidation-dependent steps in signal transduction pathways being uncovered.
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Abstract: Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays important roles in host defense and oxidative biosynthetic reactions. In addition there is growing evidence that at low levels, H2O2 also functions as a signaling agent, particularly in higher organisms. This review evaluates the evidence that H2O2 functions as a signaling agent in higher organisms in light of the known biology and biochemistry of H2O2. All aerobic organisms studied to date from prokaryotes to humans appear to tightly regulate their intracellular H2O2 concentrations at relatively similar levels. Multiple biochemical strategies for rapidly reacting with these low endogenous levels of H2O2 have been elucidated from the study of peroxidases and catalases. Welldefined biochemical pathways involved in the response to exogenous H2O2 have been described in both prokaryotes and yeast. In animals and plants, regulated enzymatic systems for generating H2O2 have been described. In addition oxidation-dependent steps in ...
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Citations
The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay
TL;DR: It is shown how an Arabidopsis thiol peroxidase, PRXIIB, senses endogenous H2O2 and regulates immune responses through a redox relay mechanism that mediates reactive oxygen species signalling during plant immunity.
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Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis
TL;DR: The hypothesis of a protective role of QSOX1 against apoptosis is strengthened, partly due to a preservation of the mitochondrial polarization generally lost after an oxidative stress.
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Peroxosolvates: Formation Criteria, H2O2 Hydrogen Bonding, and Isomorphism with the Corresponding Hydrates
Ivan Yu. Chernyshov,Ivan Yu. Chernyshov,Mikhail V. Vener,Mikhail V. Vener,Petr V. Prikhodchenko,Alexander G. Medvedev,Alexander G. Medvedev,Ovadia Lev,Andrei V. Churakov +8 more
TL;DR: In this paper, the authors used the Cambridge Structural Database to investigate the detailed environment of H2O2 molecules and hydrogen-bond patterns within true peroxosolvates.
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Disposable electrodes from waste materials and renewable sources for (bio)electroanalytical applications
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β-Pinene inhibited germination and early growth involves membrane peroxidation
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References
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