Journal Article10.1163/1568562041753025
Hyaluronic-acid-based semi-interpenetrating materials.
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TL;DR: Results indicate that molecular weight of HA significantly influences the mechanical properties of the semi-interpenetrating materials and more specifically stronger material results from the use of low-molecular-weight (LMW) HA.
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Abstract: In order to enhance the mechanical performances of hyaluronic acid (HA) without compromising its biological activity, HA has been interpenetrating with a fibrillar collagen scaffold. The semi-interpenetrating materials were obtained by mixing HA with different molecular weight and a pepsin-solubilized collagen (atelocollagen) solution, and then by inducing collagen fibrillogenesis. Results indicate that molecular weight of HA significantly influences the mechanical properties of the semi-interpenetrating materials and more specifically stronger material results from the use of low-molecular-weight (LMW) HA. According to the dynamic mechanical data the composite collagen-LMW HA has a higher elastic modulus than collagen, whereas the opposite is true for the high-molecular-weight (HMW) HA. This result highlights the role of specific interactions that occur between collagen and HA during the gel formation in controlling the network mechanical stability. LMW HA may, probably, interact more strongly with collagen during the fibrillogenesis process than HMW HA due to the higher mobility of the chains and the weaker homologous interactions. Moreover, morphological observations showed that LMW HA is intimately interdispersed within the collagen network and completely coated the fibrils, which act as mechanical support.
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Citations
Hyaluronic Acid: Incorporating the Bio into the Material.
TL;DR: How HA-based signaling regulates cell behavior is summarized and how these signals can be leveraged to create cell-instructive biomaterials are discussed.
136
Enhancement of bio-stability and mechanical properties of hyaluronic acid hydrogels by tannic acid treatment.
TL;DR: The enzymatic stability of the HA-TA hydrogels was significantly enhanced with the addition ofTA, which was attributed to the hyaluronidase inhibition activity of TA, which resulted in good resistance to degradation by reactive oxygen species, which can be generated in human tissues.
136
Hyaluronic Acid Based Hydrogels for Regenerative Medicine Applications
Assunta Borzacchiello,Luisa Russo,Birgitte M. Malle,Khadija Schwach-Abdellaoui,Luigi Ambrosio +4 more
TL;DR: It was demonstrated that processes such as sterilization and extrusion through clinical needles do not imply significant alteration of viscoelastic properties and these new hydrogels show a good stability against enzymatic degradation, which increases by increasing HA concentration and decreasing HA/DVS weight ratio.
Microsphere-integrated collagen scaffolds for tissue engineering: Effect of microsphere formulation and scaffold properties on protein release kinetics
Francesca Ungaro,Marco Biondi,Ivana d'Angelo,Laura Indolfi,Fabiana Quaglia,Paolo A. Netti,Maria Immacolata La Rotonda +6 more
TL;DR: The fine regulation of a tissue engineering construct may be obtained by an appropriate combination of microspheres and scaffolds, providing a spatial and temporal control over signalling molecule delivery.
115
Collagen-low molecular weight hyaluronic acid semi-interpenetrating network loaded with gelatin microspheres for cell and growth factor delivery for nucleus pulposus regeneration
Roman Tsaryk,Antonio Gloria,Teresa Russo,Laura Anspach,Roberto De Santis,Shahram Ghanaati,Shahram Ghanaati,Ronald E. Unger,Luigi Ambrosio,C. James Kirkpatrick +9 more
TL;DR: Collagen-LMW HA loaded with gelatin microspheres represents a good candidate material for NP tissue engineering as it combines important rheological, functional and biological features.
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References
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The chemistry, biology and medical applications of hyaluronan and its derivatives
Endre A. Balazs,Torvard C. Laurent +1 more
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TL;DR: The aim of this book is to collect within one volume information on hyaluronan, which has received rapid attention for two reasons: it has important regulative functions within cell biology; and it has become a commercially important product because of its use in ophthalmic surgery and treatment of joint diease.