Humanized mice in translational biomedical research

TL;DR: The hermeneutic circle of biology summarizes the course of experimental biology through 2500 years of the achievements of reductionist research (understanding the parts), which culminates in the authors' ability to rapidly sequence the genome.

TL;DR: A completely autologous xenotransplantation method to reconstitute the human tumor immune microenvironment in vivo without confounding allogeneic responses is developed and presented as a valuable method to study individualized human tumor microenvironments in vivo.

TL;DR: It is proposed that the humanized silkworm expressing hIR is useful for in vivo evaluation of the therapeutic activities of insulin receptor agonists.

TL;DR: Outbred mice could provide broader insight into donor and recipient determinants of allograft outcomes but their hybrid vigor and genetic diversity do not constitute a uniform barrier to tolerance induction.

TL;DR: It is demonstrated that systemic administration of human cord blood-derived CD34(+) cells to immunocompromised mice subjected to stroke 48 hours earlier induces neovascularization in the ischemic zone and provides a favorable environment for neuronal regeneration.

TL;DR: The higher levels of human CD4+ T cells and the normalization of the CD4:CD8 ratio that are observed in human PBMC-engrafted NOD/LtSz-scid/scid B2m(null) mice suggest that this system may be an excellent model for studies of HIV pathogenesis.

TL;DR: Autologous MM engraftment is likely to be considerably more efficient than in a xenogeneic host, strongly suggesting that MM autografts contribute to posttransplant relapse, and Xenografting MM precursors appear to be CD34(+)CD45(low), similar to normal progenitors.

TL;DR: Two mechanisms for EBV lymphomagenesis, slow outgrowth of rare latently-infected B cells, and more rapid transformation of uninfected bystander B cells by replicating virus are suggested.