Human TERT promoter mutations as a prognostic biomarker in glioma.
Branka Powter,Sarah A Jeffreys,Heena Sareen,Adam Cooper,Adam Cooper,Daniel Brungs,Joseph W. Po,Tara L. Roberts,Tara L. Roberts,Eng-Siew Koh,Eng-Siew Koh,Kieran F. Scott,Mila Sajinovic,Joey Yusof Vessey,Paul de Souza,Therese M. Becker,Therese M. Becker +16 more
TL;DR: In this article, the potential for pTERT mutation analysis, via liquid biopsy, for its potential use in personalised cancer therapy was explored, with the main focus being on brain cancer.
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Abstract: The TERT promoter (pTERT) mutations, C228T and C250T, play a significant role in malignant transformation by telomerase activation, oncogenesis and immortalisation of cells. C228T and C250T are emerging as important biomarkers in many cancers including glioblastoma multiforme (GBM), where the prevalence of these mutations is as high as 80%. Additionally, the rs2853669 single nucleotide polymorphism (SNP) may cooperate with these pTERT mutations in modulating progression and overall survival in GBM. Using liquid biopsies, pTERT mutations, C228T and C250T, and other clinically relevant biomarkers can be easily detected with high precision and sensitivity, facilitating longitudinal analysis throughout therapy and aid in cancer patient management.In this review, we explore the potential for pTERT mutation analysis, via liquid biopsy, for its potential use in personalised cancer therapy. We evaluate the relationship between pTERT mutations and other biomarkers as well as their potential clinical utility in early detection, prognostication, monitoring of cancer progress, with the main focus being on brain cancer.
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Tumor biomarkers for diagnosis, prognosis and targeted therapy.
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TL;DR: This review summarizes the discovery and development of tumor biomarkers for cancer diagnosis, prognosis, and targeted therapy, highlighting recent advancements in biomarker-based anticancer therapies and their potential to improve precision medicine and cancer patient outcomes.
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Molecular Biomarkers in Glioblastoma: A Systematic Review and Meta-Analysis
TL;DR: MGMT promoter methylation and IDH1 mutation are significantly associated with better OS in GBM patients, and no significant associations were found between EGFR amplification or overexpression with OS.
Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances
Tsimur N. Hasanau,Eduard Pisarev,Olga Kisil,Naosuke Nonoguchi,Florence Le Calvez-Kelm,Maria Zvereva +5 more
TL;DR: The methodological approaches used to determine mutations in the promoter region of the TERT gene in tumors of the central nervous system, including mass spectrometry, magnetic resonance imaging, next-generation sequencing, and nanopore sequencing are considered.
Occurrence, functionality and abundance of the TERT promoter mutations
TL;DR: In this paper, the authors discuss the occurrence and impact of the TERT promoter mutations and highlight the mechanism of TERT activation, and further deliberate on the foundational question of the abundance of the telomerase reverse transcriptase (TERT) gene and a general dearth of functional mutations within noncoding sequences.
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Nomogram for predicting early recurrence in patients with high-grade gliomas.
TL;DR: In this paper , the authors developed a nomogram to predict early recurrence of high grade glioma (HGG) based on clinical pathology, genetic factors, and magnetic resonance imaging parameters.
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