Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles.
Katherine N. Ward,Hoe Nam Leong,Elisabeth P. Nacheva,Julie Howard,Claire Atkinson,Nicholas W S Davies,Paul D. Griffiths,Duncan A. Clark +7 more
TL;DR: Six immunocompetent patients with human herpesvirus 6 (HHV- 6) chromosomal integration had HHV-6 and β-globin DNA quantified in various samples by PCR, demonstrating that viral integration is not confined to blood cells.
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Abstract: Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and β-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log10 copies/milliliter) in blood was 7.0 (≥1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (≥1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log10 copies)/hair follicle was 4.2 (≥1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.
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G. V. Volynets,A.I. Khavkin,A. V. Nikitin +2 more
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TL;DR: It is shown that most researchers unanimously conclude that the main attention should be paid to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpes simplex virus type 6 (HHV-6), which are found in the mucous membrane of the colon in patients with IBD.
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HHV-6 is ubiquitously found using Western blot in tonsils and adenoid tissues of healthy people.
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TL;DR: This report examined tonsils and adenoid tissues of 54 patients who had undergone tonsillectomy or adenoidsectomy without any evidence of acute infection for the presence of latent HHV-6 infection and found that 100% of tonsil tissues were positive for HHv-6 with WB, 40% oftonsils were positive with PCR and no tonsil was positive with IHC.
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R. Bella,Maria Dolci,Mariano Ferraresso,Rosalia Ticozzi,Luciana Ghio,Jacopo Rizzo,Lucia Signorini,Sonia Villani,Francesca Elia,Pasquale Ferrante,Serena Delbue +10 more
TL;DR: HHV-6 infection in immunosuppression setting was as common as those of HPyVs that are commonly recognized as opportunistic agents.
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Duncan A. Clark,Elisabeth P. Nacheva,Hoe Nam Leong,Diana Brazma,Ying Ting Li,Edward H. Tsao,Hubertus Buyck,Claire Atkinson,Heather M. Lawson,Michael N. Potter,Paul D. Griffiths +10 more
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