Human Dorsal Root Ganglia.
TL;DR: This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of humanDRG neurons, in particular nociceptive neurons.
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Abstract: Sensory neurons with cell bodies situated in dorsal root ganglia convey information from external or internal sites of the body such as actual or potential harm, temperature or muscle length to the central nervous system. In recent years, large investigative efforts have worked toward an understanding of different types of DRG neurons at transcriptional, translational, and functional levels. These studies most commonly rely on data obtained from laboratory animals. Human DRG, however, have received far less investigative focus over the last 30 years. Nevertheless, knowledge about human sensory neurons is critical for a translational research approach and future therapeutic development. This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of human DRG neurons, in particular nociceptive neurons.
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TL;DR: How SGCs are altered in rodent models of four common types of pain: systemic inflammation (sickness behaviour), post-surgical pain, diabetic neuropathic pain and post-herpetic pain is described.
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
TL;DR: In this article , the authors used spatial transcriptomics to molecularly characterize transcriptomes of single dorsal root ganglia (DRG) neurons from eight organ donors, identifying 12 clusters of human sensory neurons, 5 of which are C nociceptors, as well as 1 C low-threshold mechanoreceptors (LTMRs), 1 Aβ nocicusor, 2 Aδ,2 Aβ, and 1 proprioceptor subtypes.
261
Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization
TL;DR: Insight is offered into the spatial and functional organization of neuronal cell subpopulations in the rodent and human DRG and support the idea that sensory system organizational principles are likely different between both species.
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Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain.
Jussi Kupari,Dmitry Usoskin,Marc Parisien,Daohua Lou,Yizhou Hu,Michael Fatt,Peter Lönnerberg,Mats Spångberg,B.M. Eriksson,Nikolaos Barkas,Peter V. Kharchenko,Karin Loré,Samar Khoury,Luda Diatchenko,Patrik Ernfors +14 more
TL;DR: In this article, the authors classify non-human primate dorsal root ganglion sensory neurons based on their transcriptome and map human pain heritability to neuronal types to identify the cellular origin of chronic pain.
References
Human Nav1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons
Chongyang Han,Mark Estacion,Jianying Huang,Dymtro Vasylyev,Peng Zhao,Sulayman D. Dib-Hajj,Stephen G. Waxman +6 more
TL;DR: Using techniques that include voltage clamp, current clamp, and dynamic clamp in dorsal root ganglion (DRG) neurons, it is shown that human Na(v)1.8 channels display slower inactivation kinetics and produce larger persistent current and ramp current than previously reported in other species.
A guide to the perplexed on the specificity of antibodies.
TL;DR: The principles of antibody action are considered and how they define a set of rules for what information should be obtained by the investigator before using an antibody in a serious scientific investigation are considered.
Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies.
Uma Anand,Yiangos Yiangou,Marco Sinisi,Marco Sinisi,Michael Fox,Michael Fox,Anthony MacQuillan,Anthony MacQuillan,Tom Quick,Tom Quick,Yuri E. Korchev,C. Bountra,T McCarthy,Praveen Anand +13 more
TL;DR: The major AT2R ligand in human peripheral nerves is AngII, and its levels are maintained in injured nerves, while NGF significantly increased signal intensity of p38 and p42/44 MAPK, which was reversed by EMA401.
Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.
TL;DR: It is proposed that the BKi channels in small diameter DRG sensory neurons might play an important role in regulating nociceptive input to the central nervous system (CNS) through regulation of β‐subunits.
Sodium channels in pain disorders: pathophysiology and prospects for treatment.
TL;DR: This chapter discusses clinical pain syndromes, which can be traced back to specific causes such as traumatic or metabolic nerve injuries, but most cases have no clear causative event/injury.
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