Human Dorsal Root Ganglia.
TL;DR: This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of humanDRG neurons, in particular nociceptive neurons.
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Abstract: Sensory neurons with cell bodies situated in dorsal root ganglia convey information from external or internal sites of the body such as actual or potential harm, temperature or muscle length to the central nervous system. In recent years, large investigative efforts have worked toward an understanding of different types of DRG neurons at transcriptional, translational, and functional levels. These studies most commonly rely on data obtained from laboratory animals. Human DRG, however, have received far less investigative focus over the last 30 years. Nevertheless, knowledge about human sensory neurons is critical for a translational research approach and future therapeutic development. This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of human DRG neurons, in particular nociceptive neurons.
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Citations
Emerging importance of satellite glia in nervous system function and dysfunction
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TL;DR: How SGCs are altered in rodent models of four common types of pain: systemic inflammation (sickness behaviour), post-surgical pain, diabetic neuropathic pain and post-herpetic pain is described.
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
TL;DR: In this article , the authors used spatial transcriptomics to molecularly characterize transcriptomes of single dorsal root ganglia (DRG) neurons from eight organ donors, identifying 12 clusters of human sensory neurons, 5 of which are C nociceptors, as well as 1 C low-threshold mechanoreceptors (LTMRs), 1 Aβ nocicusor, 2 Aδ,2 Aβ, and 1 proprioceptor subtypes.
261
Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization
TL;DR: Insight is offered into the spatial and functional organization of neuronal cell subpopulations in the rodent and human DRG and support the idea that sensory system organizational principles are likely different between both species.
171
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain.
Jussi Kupari,Dmitry Usoskin,Marc Parisien,Daohua Lou,Yizhou Hu,Michael Fatt,Peter Lönnerberg,Mats Spångberg,B.M. Eriksson,Nikolaos Barkas,Peter V. Kharchenko,Karin Loré,Samar Khoury,Luda Diatchenko,Patrik Ernfors +14 more
TL;DR: In this article, the authors classify non-human primate dorsal root ganglion sensory neurons based on their transcriptome and map human pain heritability to neuronal types to identify the cellular origin of chronic pain.
References
Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy
Jessica R. Lakritz,Ayman Bodair,Neal Shah,Ryan O'Donnell,Michael Polydefkis,Andrew D. Miller,Tricia H. Burdo +6 more
TL;DR: It is demonstrated that newly recruited MAC387(+)BrdU(+) macrophages may play a significant role in DRG pathogenesis, and increased recruitment of macrophage to DRG is associated with severe DRG histopathology and IENFD loss.
35
Inflammatory mediator-induced modulation of GABAA currents in human sensory neurons.
TL;DR: The results highlight potentially important species differences in the properties of ion channels present in their native environment and suggest the use of human sensory neurons may be a valuable tool to test compounds prior to use in humans.
33
Morphometric evaluation of the sacral dorsal root ganglia: A cadaveric study
Nabil A. Ebraheim,Jike Lu +1 more
TL;DR: The S1 DRG, with its its relatively larger dimensions and its intracanalar position relative to the other sacral DRGs, may be susceptible to compression by L5-S1 disk herniation and its intraforaminal position may predispose it to injury during S1 or S2 pedicle screw placement.
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Epidermal growth factor receptor in adult human dorsal root ganglia.
TL;DR: It is demonstrated that EGFr, and other related proteins containing the epitope labeled with the antibody F4, are responsible for the EGFr IR reported in DRG, and heterogeneity in the expression of EGFr-like IR in adult human primary sensory neurons, which suggests different responsiveness to their ligands.
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Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
Éva Borbély,Zsófia Hajna,Katalin Sándor,László Kereskai,István János Tóth,Erika Pintér,Péter Nagy,János Szolcsányi,John P. Quinn,Andreas Zimmer,James P. Stewart,Christopher J. Paige,Christopher J. Paige,Alexandra Berger,Alexandra Berger,Zsuzsanna Helyes +15 more
TL;DR: While NK1 receptors mediate its antihyperalgesic actions, the involvement of another receptor in histopathological changes and IL-1β production is suggested.
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