Journal Article10.1126/SCIROBOTICS.AAY6626
Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.
Gwangjun Go,Sin-Gu Jeong,Ami Yoo,Jiwon Han,Byungjeon Kang,Seok-Jae Kim,Kim Tien Nguyen,Zhen Jin,Chang-Sei Kim,Yu Ri Seo,Ju Yeon Kang,Ju Yong Na,Eun Kyoo Song,Yong-Yeon Jeong,Jong Keun Seon,Jong-Oh Park,Eunpyo Choi +16 more
- 22 Jan 2020
- Vol. 5, Iss: 38
179
TL;DR: The efficacy of the microrobot system was assessed in the cartilage defect model of rabbit knee with the aim to obtain clinical trial approval and present an in vivo trial to verify the efficacy.
read more
Abstract: Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to date is only in its proof-of-concept stage. To use the microrobot in a clinical stage, biocompatibility and biodegradation materials should be considered in the microrobot, and its efficacy needs to be verified using an in vivo model. In this study, we propose a human adipose-derived MSC-based medical microrobot system for knee cartilage regeneration and present an in vivo trial to verify the efficacy of the microrobot using the cartilage defect model. The microrobot system consists of a microrobot body capable of supporting MSCs, an electromagnetic actuation system for three-dimensional targeting of the microrobot, and a magnet for fixation of the microrobot to the damaged cartilage. Each component was designed and fabricated considering the accessibility of the patient and medical staff, as well as clinical safety. The efficacy of the microrobot system was then assessed in the cartilage defect model of rabbit knee with the aim to obtain clinical trial approval.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Construction of PLGA Porous Microsphere-Based Artificial Pancreatic Islets Assisted by the Cell Centrifugation Perfusion Technique
TL;DR: In this article , the authors used poly(lactic-co-glycolic acid) microspheres (PMs) to construct multicellular artificial pancreatic islets.
3
Encoded Magnetization for Programmable Soft Miniature Machines by Covalent Assembly of Modularly Coupled Microgels
Tanyong Wei,Ruizhou Zhao,Lijun Fang,Zongze Li,Ming Yang,Zhen Zhan,U. K. Cheang,Chengzhi Hu +7 more
TL;DR: Researchers develop a method for programmable soft machines using covalently assembled microgels with modular magnetization profiles, enabling the creation of complex, durable, and versatile devices for various applications, including cell-laden hydrogels, magnetic swimmers, and drug delivery systems.
3
Swarm Autonomy: From Agent Functionalization to Machine Intelligence.
Yibin Wang,Hui Chen,Jinbo Liu,Li Zhang,Jiangfan Yu +4 more
TL;DR: This review presents a comprehensive summary and perspective of synthetic swarms, to bridge the gap between the microscale individual agents and potential applications of synthetic swarms.
3
3D Navigation Control of Untethered Magnetic Microrobot in Centimeter-Scale Workspace Based on Field-of-View Tracking Scheme
01 Jun 2022
TL;DR: In this article , an enhanced rapidly exploring random tree algorithm is proposed to avoid obstacles in the complex environment, and a field-of-view tracking method is developed using a specific image definition evaluation algorithm.
3
References
Repair and tissue engineering techniques for articular cartilage
Eleftherios Makris,Andreas H. Gomoll,Konstantinos N. Malizos,Jerry C. Hu,Kyriacos A. Athanasiou +4 more
TL;DR: Current, widely used clinical repair techniques for resurfacing articular cartilage defects and a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular Cartilage are described.
1.1K
Cell interactions with three-dimensional matrices.
TL;DR: Recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments are examined, illuminating mechanisms of cell-matrix interactions in living organisms.
987
From cell-ecm interactions to tissue engineering
TL;DR: This review considers recent advances in knowledge about cell–ECM interactions and the general principles of biomaterial design for tissue engineering are considered, with same examples.
704
In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams.
Lichun Lu,Susan J. Peter,Michelle D. Lyman,Hui-Lin Lai,Susan M. Leite,Janet A. Tamada,S. Uyama,Joseph P. Vacanti,Robert Langer,Antonios G. Mikos +9 more
TL;DR: The results suggest that the polymer composition and environmental conditions have significant effects on the degradation rate of porous PLGA foams, with significantly shorter half-lives of PLGA 50: 50 compared to 85: 15 foams indicated their faster degradation both in vitro and in vivo.
702
OctoMag: An electromagnetic system for 5-DOF wireless micromanipulation
Bradley E. Kratochvil,Michael P. Kummer,Jake J. Abbott,Ruedi Borer,Olgaç Ergeneman,Bradley J. Nelson +5 more
- 03 May 2010
TL;DR: Five-degree-of-freedom (5-DOF) wireless magnetic control of a fully untethered microrobot (3- DOF position and 2-DOf pointing orientation) is demonstrated.
Related Papers (5)
Ouajdi Felfoul,Mahmood Mohammadi,Samira Taherkhani,Samira Taherkhani,Dominic de Lanauze,Yong Zhong Xu,Dumitru Loghin,Sherief Essa,Sherief Essa,Sylwia Jancik,Daniel Houle,Michel Lafleur,Louis Gaboury,Maryam Tabrizian,Neila Kaou,Michael Atkin,Té Vuong,Gerald Batist,Nicole Beauchemin,Danuta Radzioch,Sylvain Martel +20 more