Journal Article10.1007/BF02703906
How viruses damage cells: alterations in plasma membrane function
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TL;DR: It is concluded that clinical symptoms may result from cell damage caused by virally induced alterations of plasma membrane function in otherwise intact cells.
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Abstract: The effect of viruses on plasma membrane function has been studied in two types of situation: (i) during the toxin-like action of paramyxoviruses when fusing with susceptible cells, and (ii) during an infectious cycle initiated by different viruses in various cell types.
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Citations
Virus, toxin, complement: Common actions and their prevention by Ca2+ Or Zn2+
TL;DR: In quite different agents induce a similar type of lesion, leakage is reduced at low ionic strenth, and is prevented by divalent cations such as Ca2+ or Zn2+, suggesting a possible therapeutic approach to the containment of several membrane‐damaging diseases.
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A novel role of Ca2+ and Zn2+: protection of cells against membrane damage.
TL;DR: Ca2+ and Zn2+ protect against cytotoxic agents by promoting pore closure and may play a beneficial role in this regard in certain disease states.
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Ca2+ and the interaction of pore-formers with membranes
TL;DR: It is concluded that divalent cations are able to protect cells against the damaging effects of certain viruses, toxins or the components of activated complement in a manner that is worthy of further investigation.
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Can viral envelope proteins act as or induce proton channels
TL;DR: It is demonstrated that the fusion events induced by three viruses of different families, namely Semliki Forest, vesicular stomatitis and influenza, share common features and a sudden drop of the intracellular pH—below the critical eextracellular pH required to trigger “fusion from within” (FFWI)—is observed.
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Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle
TL;DR: In a wide variety of excitable cells the transmembrane exchange of the monovalent marine cations Na and K can be considered the substantial basis of bioelectric membrane activity, whereas Ca ions are required as mediators when, by this superfi cial process, intracellular reactions such as muscular contraction, glandular secre tion, or liberation of transmitter substances are initiated.
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R 24 571: A potent inhibitor of calmodulin-activated enzymes
TL;DR: Being much more potent, and devoid of affinity towards several receptors, R 24 571 is proposed as a more specific and useful tool for studying the involvement of calmodulin in biological processes than the currently used compounds.
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