Open Access
How to Use an Article About Therapy or Prevention
Gordon H. Guyatt,David L. Sackett,Deborah J. Cook +2 more
- 01 Jan 1995
484
TL;DR: A 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease is seeing an internal medicine resident in a rheumatology rotation.
read more
Abstract: You are working as an internal medicine resident in a rheumatology rotation and are seeing a 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease. A renal biopsy has shown diffuse proliferative nephritis. A year ago, her creatinine was 140 micromoles/litre, six months ago 180, and in a blood sample taken a week before this clinic visit, 220. Over the last year she has been taking prednisone, and over the last six months, cyclophosphamide, both in appropriate doses.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A prospective, randomized, double-blind, placebo-controlled trial of multimodal intraoperative analgesia for laparoscopic excision of endometriosis
Michael F. Costello,Michael F. Costello,Jason Abbott,Jason Abbott,S G Katz,Thierry G. Vancaillie,Thierry G. Vancaillie,Sally Wilson +7 more
TL;DR: The use of multimodal intraoperative analgesia at laparoscopic excision of endometriosis reduces postoperative opioid requirements, and this study was terminated prematurely.
16
Cochrane in CORR ® : Arthroplasties (With and Without Bone Cement) For Proximal Femoral Fractures in Adults
TL;DR: In comparison to unipolar hemiarthroplasty, bipolar implants are suggested to minimize acetabular wear while mainA Note from the Editor-in-Chief: I am pleased to announce the partnership between CORR, The Cochrane Collaboration, and McMaster University’s Evidence-Based Orthopaedics Group for a new column, called Cochrane in CORR.
16
Appropriate methods to assess the effectiveness and efficacy of treatments or interventions to control cancer pain.
TL;DR: Efficacy trials such as randomised controlled trials (RCT) are experimental studies and estimate the maximum potential benefit to be derived from an intervention in ideal circumstances and under a controlled environment.
16
Evidence-based decision making in small animal therapeutics.
TL;DR: With a growing number of evidence-based resources being developed for use in veterinary medicine, the time is right for academicians, practitioners, and students to embrace the positive elements ofevidence-based veterinary medicine.
16
Translating evidence-based decision making into practice: appraising and applying the evidence
Syrene A. Miller,Jane L. Forrest +1 more
TL;DR: The purpose of this article is to discuss the critical appraisal criteria used to assess the methodological quality of a study and how appraising the evidence helps to answer questions and how to translate the evidence into everyday practice.
16
References
•Book
Clinical Epidemiology: A Basic Science for Clinical Medicine
David L. Sackett
- 01 Jan 1985
TL;DR: Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
4K
•Book
Users' Guides to the Medical Literature
Gordon H. Guyatt,Drummond Rennie +1 more
- 01 Jan 2001
TL;DR: Without a way of critically appraising the information they receive, clinicians are relatively helpless in deciding what new information to learn and decide how to modify their practice.
3.4K
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
3.1K
An assessment of clinically useful measures of the consequences of treatment.
TL;DR: The goal is to provide a clear picture of the individual components of the immune system and provide a strategy for individualized treatment of these components according to their Kesslerian importance.
1.6K
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
Roger C. Bone,Charles J. Fisher,Terry P. Clemmer,Gus J. Slotman,Craig A. Metz,Robert A. Balk +5 more
TL;DR: It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
1.4K
Related Papers (5)
Gordon H. Guyatt,Drummond Rennie +1 more
- 01 Jan 2001
Gordon H. Guyatt,David L. Sackett,Deborah J. Cook,Gordon Guyatt,Eric B Bass,Patrick Brill-Edwards,George P. Browman,Deborah Cook,Michael E. Farkouh,Hertzel C. Gerstein,Brian Haynes,Robert Hayward,Anne Holbrook,Roman Jaeschke,Elizabeth F. Juniper,Andreas Laupacis,Hui Lee,Mitchell Levine,Virginia Moyer,Jim Nishikawa,Andrew D Oxman,Ameen Patel,John Philbrick,W. Scott Richardson,Stephane Sauve,David L. Sackett,Jack Sinclair,K. S. Trout,Peter Tugwell,Sean Tunis,Stephen D. Walter,John W Williams,Mark Wilson +32 more
David L. Sackett
- 14 Mar 2000
Roman Jaeschke,Gordon H. Guyatt,David L. Sackett,Eric Bass,Patrick Brill-Edwards,George P. Browman,Deborah J. Cook,Michael E. Farkouh,Hertzel C. Gerstein,Brian Haynes,Robert Hayward,Anne Holbrook,Elizabeth F. Juniper,Hui Lee,Mitchell Levine,Virginia Moyer,Jim Nishikawa,Andrew D Oxman,Ameen Patel,John Philbrick,W. Scott Richardson,Stephane Sauve,David L. Sackett,Jack Sinclair,K. S. Trout,Peter Tugwell,Sean Tunis,Stephen D. Walter,Mark C. Wilson +28 more