Open Access
How to Use an Article About Therapy or Prevention
Gordon H. Guyatt,David L. Sackett,Deborah J. Cook +2 more
- 01 Jan 1995
484
TL;DR: A 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease is seeing an internal medicine resident in a rheumatology rotation.
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Abstract: You are working as an internal medicine resident in a rheumatology rotation and are seeing a 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease. A renal biopsy has shown diffuse proliferative nephritis. A year ago, her creatinine was 140 micromoles/litre, six months ago 180, and in a blood sample taken a week before this clinic visit, 220. Over the last year she has been taking prednisone, and over the last six months, cyclophosphamide, both in appropriate doses.
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Citations
Need for evidence-based practice in prosthodontics.
TL;DR: With appropriate skills and the availability of literature searching hardware and software, evidence-based practice is a powerful means for the practitioner to establish the effectiveness of individual patient treatment and to prevent the diminution of clinical skills over the course of a career.
45
Transfusion interventions in critical bleeding requiring massive transfusion: a systematic review.
Zoe McQuilten,Gemma Crighton,Sunelle Engelbrecht,Robert Gotmaker,Susan J Brunskill,Michael F. Murphy,Erica M. Wood +6 more
TL;DR: Overall, limited new evidence was identified and substantial evidence gaps remain, particularly with regard to the effect of component therapies, including ratio of RBC to components therapies, on patient outcomes.
44
Computerized protocols and bedside decision support.
TL;DR: The author discusses the potential advantages that this decision-support approach, with bedside computerized protocols, brings to the healthcare delivery system, and what contributions to clinical care and to clinical research might be anticipated from its widespread application.
44
Evidence-based care of musculoskeletal facial pain: implications for the clinical science of dentistry
TL;DR: The authors assert that advancement of dentistry as a clinical science has been hampered by a failure to practice evidence-based care, which incorporates principles derived from clinical epidemiology.
42
References
•Book
Clinical Epidemiology: A Basic Science for Clinical Medicine
David L. Sackett
- 01 Jan 1985
TL;DR: Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
4K
•Book
Users' Guides to the Medical Literature
Gordon H. Guyatt,Drummond Rennie +1 more
- 01 Jan 2001
TL;DR: Without a way of critically appraising the information they receive, clinicians are relatively helpless in deciding what new information to learn and decide how to modify their practice.
3.4K
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
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An assessment of clinically useful measures of the consequences of treatment.
TL;DR: The goal is to provide a clear picture of the individual components of the immune system and provide a strategy for individualized treatment of these components according to their Kesslerian importance.
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A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
Roger C. Bone,Charles J. Fisher,Terry P. Clemmer,Gus J. Slotman,Craig A. Metz,Robert A. Balk +5 more
TL;DR: It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
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