Open Access
How to Use an Article About Therapy or Prevention
Gordon H. Guyatt,David L. Sackett,Deborah J. Cook +2 more
- 01 Jan 1995
484
TL;DR: A 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease is seeing an internal medicine resident in a rheumatology rotation.
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Abstract: You are working as an internal medicine resident in a rheumatology rotation and are seeing a 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease. A renal biopsy has shown diffuse proliferative nephritis. A year ago, her creatinine was 140 micromoles/litre, six months ago 180, and in a blood sample taken a week before this clinic visit, 220. Over the last year she has been taking prednisone, and over the last six months, cyclophosphamide, both in appropriate doses.
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Citations
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Should we patch corneal abrasions? A meta-analysis.
Flynn Ca,D'Amico F,Smith G +2 more
TL;DR: Eye patching was not found to improve healing rates or reduce pain in patients with corneal abrasions, and the route of harmless nonintervention in treating cornea abrasions is recommended.
67
Evidence-based medicine. Interpreting studies and setting policy.
Steven H. Woolf,James N. George +1 more
TL;DR: There is little evidence that either the rigor of the methods or the guidelines themselves have a meaningful effect on practice behavior or patient outcomes and this absence of response has stimulated a closer look at the barriers to behavior change and the design of thoughtful implementation strategies.
62
Persistence of Medical Change at Implementation of Clinical Guidelines on Medical Practice: A Controlled Study in a Cancer Network
Isabelle Ray-Coquard,Thierry Philip,Guy de Laroche,Xavier Froger,Jean-Philippe Suchaud,Alain Voloch,Hélène Mathieu-Daudé,A. Lurkin,Fadila Farsi,Pierre Bertrand,Franck Chauvin +10 more
TL;DR: The CPG program for cancer management produced persistent changes in medical practice in the cancer network in terms of conformity with CPG.
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Systematic review and meta-analysis of randomized controlled trials comparing botulinum toxin injection with lateral internal sphincterotomy for chronic anal fissure
TL;DR: Botulinum toxin injection was associated with a higher rate of recurrent disease and LIS was more effective in healing chronic anal fissure.
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References
•Book
Clinical Epidemiology: A Basic Science for Clinical Medicine
David L. Sackett
- 01 Jan 1985
TL;DR: Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
4K
•Book
Users' Guides to the Medical Literature
Gordon H. Guyatt,Drummond Rennie +1 more
- 01 Jan 2001
TL;DR: Without a way of critically appraising the information they receive, clinicians are relatively helpless in deciding what new information to learn and decide how to modify their practice.
3.4K
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
3.1K
An assessment of clinically useful measures of the consequences of treatment.
TL;DR: The goal is to provide a clear picture of the individual components of the immune system and provide a strategy for individualized treatment of these components according to their Kesslerian importance.
1.6K
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
Roger C. Bone,Charles J. Fisher,Terry P. Clemmer,Gus J. Slotman,Craig A. Metz,Robert A. Balk +5 more
TL;DR: It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
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