Open Access
How to Use an Article About Therapy or Prevention
Gordon H. Guyatt,David L. Sackett,Deborah J. Cook +2 more
- 01 Jan 1995
484
TL;DR: A 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease is seeing an internal medicine resident in a rheumatology rotation.
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Abstract: You are working as an internal medicine resident in a rheumatology rotation and are seeing a 19 year-old woman who has had systemic lupus erythematosus diagnosed on the basis of a characteristic skin rash, arthritis, and renal disease. A renal biopsy has shown diffuse proliferative nephritis. A year ago, her creatinine was 140 micromoles/litre, six months ago 180, and in a blood sample taken a week before this clinic visit, 220. Over the last year she has been taking prednisone, and over the last six months, cyclophosphamide, both in appropriate doses.
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Citations
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Intention-to-treat analysis: who is in? Who is out?
Robin L. Kruse,Brian S. Alper,Carin E Reust,James J. Stevermer,Scott Shannon,Randy H Williams +5 more
TL;DR: To assess whether the term "intention to treat" (ITT) predicts inclusion of all randomized subjects in the analysis, 100 randomly selected reports of randomized trials that mentioned analysis by ITT were reviewed.
77
Methodologies and study designs relevant to medical education research
TL;DR: This paper discusses both qualitative and quantitative approaches to educational research, and concludes with an overview of how educational researchers should describe the study design and methods in order to provide transparency and clarity.
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How useful are cholinesterase inhibitors in the treatment of Alzheimer's disease? A number needed to treat analysis.
Gill Livingston,Cornelius Katona +1 more
TL;DR: To report on a Numbers Needed to Treat (NNT) analysis of the literature identified through a systematic review of trials of cholinesterase inhibitors in Alzheimer's Disease.
73
Management of nonalcoholic fatty liver disease: an evidence-based clinical practice review
Juan Pablo Arab,Roberto Candia,Rodrigo Zapata,Cristian Pérez Muñoz,Juan P Arancibia,Jaime Poniachik,Alejandro Soza,Francisco Fuster,J.R. Brahm,Edgar Sanhueza,Jorge E. Contreras,M Carolina Cuellar,Marco Arrese,Arnoldo Riquelme +13 more
TL;DR: Current NAFLD management is rapidly evolving, and new pathophysiology-based therapies are expected to be introduced in the near future.
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Targeting the Use of Reminders and Notifications for Uptake by Populations (TURNUP): a systematic review and evidence synthesis
Sionnadh McLean,Melanie Gee,Andrew Booth,Sarah Salway,Susan Nancarrow,Mark Cobb,Sadiq Bhanbhro +6 more
TL;DR: This project explores the differential effect of reminder systems for different segments of the population for improving attendance, cancellation and rescheduling of appointments and found that reminder systems are consistently effective at reducing non-attendance at appointments, regardless of health-care setting or patient subgroups.
73
References
•Book
Clinical Epidemiology: A Basic Science for Clinical Medicine
David L. Sackett
- 01 Jan 1985
TL;DR: Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
4K
•Book
Users' Guides to the Medical Literature
Gordon H. Guyatt,Drummond Rennie +1 more
- 01 Jan 2001
TL;DR: Without a way of critically appraising the information they receive, clinicians are relatively helpless in deciding what new information to learn and decide how to modify their practice.
3.4K
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
3.1K
An assessment of clinically useful measures of the consequences of treatment.
TL;DR: The goal is to provide a clear picture of the individual components of the immune system and provide a strategy for individualized treatment of these components according to their Kesslerian importance.
1.6K
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
Roger C. Bone,Charles J. Fisher,Terry P. Clemmer,Gus J. Slotman,Craig A. Metz,Robert A. Balk +5 more
TL;DR: It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
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