Journal Article10.1002/SIM.1187
How should meta-regression analyses be undertaken and interpreted?
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TL;DR: The examples considered in this paper show the tension between the scientific rationale for using meta-regression and the difficult interpretative problems to which such analyses are prone.
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Abstract: SUMMARY Appropriate methods for meta-regression applied to a set of clinical trials, and the limitations and pitfalls in interpretation, are insuciently recognized. Here we summarize recent research focusing on these issues, and consider three published examples of meta-regression in the light of this work. One principal methodological issue is that meta-regression should be weighted to take account of both within-trial variances of treatment eects and the residual between-trial heterogeneity (that is, heterogeneity not explained by the covariates in the regression). This corresponds to random eects meta-regression. The associations derived from meta-regressions are observational, and have a weaker interpretation than the causal relationships derived from randomized comparisons. This applies particularly when averages of patient characteristics in each trial are used as covariates in the regression. Data dredging is the main pitfall in reaching reliable conclusions from meta-regression. It can only be avoided by prespecication of covariates that will be investigated as potential sources of heterogeneity. However, in practice this is not always easy to achieve. The examples considered in this paper show the tension between the scientic rationale for using meta-regression and the dicult interpretative problems to which such analyses are prone. Copyright ? 2002 John Wiley & Sons, Ltd.
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References
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Pharmacological interventions for somatoform disorders in adults.
Maria Kleinstäuber,Michael Witthöft,Andrés Steffanowski,Harm W.J. van Marwijk,Wolfgang Hiller,Michael J. Lambert +5 more
TL;DR: A systematic review and meta-analysis of placebo-controlled studies examined the efficacy and tolerability of different types of antidepressants, the combination of an antidepressant and an antipsychotic, antipsychotics alone, or natural products in adults with somatoform disorders in adults to improve optimal treatment decisions.
11.5K
•Book
Statistical Methods for Meta-Analysis
Larry V. Hedges,Ingram Olkin +1 more
- 01 Jan 1985
TL;DR: In this article, the authors present a model for estimating the effect size from a series of experiments using a fixed effect model and a general linear model, and combine these two models to estimate the effect magnitude.
10.7K
A simulation study of the number of events per variable in logistic regression analysis.
Peter Peduzzi,John Concato,John Concato,Elizabeth Kemper,Elizabeth Kemper,Theodore R. Holford,Alvan R. Feinstein,Alvan R. Feinstein +7 more
TL;DR: Findings indicate that low EPV can lead to major problems, and the regression coefficients were biased in both positive and negative directions, and paradoxical associations (significance in the wrong direction) were increased.
8K
The Cochrane Database of Systematic Reviews
Cochrane Acute,Diederik van de Beek +1 more
- 01 Jan 2004
TL;DR: The findings showed that UCS results in less blood loss when compared to MES and EBVS, and operating time was shorter when EBVS was used compared toMES, and no difference in complications between all three instruments were reported.