How Does the Ketogenic Diet Work? Four Potential Mechanisms
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TL;DR: Experimental evidence is provided for 4 distinct mechanisms that could contribute to the antiseizure and other beneficial effects of the ketogenic diet.
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Abstract: The ketogenic diet and its newer variants are clinically useful in treating epilepsy. They can also have antiepileptogenic properties and can eventually have a role in treating other neurologic and nonneurologic conditions. Despite being nearly a century old, identifying the molecular underpinnings of the ketogenic diet has been challenging. However, recent studies provide experimental evidence for 4 distinct mechanisms that could contribute to the antiseizure and other beneficial effects of these diets. These mechanisms include carbohydrate reduction, activation of adenosine triphosphate (ATP)-sensitive potassium channels by mitochondrial metabolism, inhibition of the mammalian target of rapamycin pathway, and inhibition of glutamatergic excitatory synaptic transmission.
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Darcy A. Krueger,Marguerite M. Caré,Katherine D. Holland,Karen Agricola,Cynthia Tudor,Prajakta Mangeshkar,Kimberly Wilson,Anna W. Byars,Tarek Sahmoud,David Neal Franz +9 more
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