How does DNA methylation repress transcription

TL;DR: Außerdem, dass in Brustkrebs-Zelllinien dieser Promotor durch DNA-Methylierung stillgelegt ist, liefert eine Erklarung fur die differentielle Expression von uberlappenden miRNA Genen, wie sie von uns and anderen Arbeitsgruppen beobachtet worden ist.

TL;DR: In this paper , a quantitative polymerase chain reaction (qPCR)-based assessment of primordial germ cells (PGC) and sex determination (SD) genes during developmental stages in Atlantic salmon embryos is presented.

TL;DR: It is found that there is hypomethylation in gastrointestinal tumors when compared with the peritumoral tissue and there is hypermethylation in all cell lines analyzed with a pattern that is characteristic of each cell type revealing specific genomic reorganizations.

TL;DR: It is demonstrated that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes in mutant mice that are deficient in DNA methyltransferase activity.

TL;DR: It has become increasingly difficult to hold that reversible promoter methylation is commonly involved in developmental gene control; instead, suppression of parasitic sequence elements appears to be the primary function of cytosine methylation, with crucial secondary roles in allele-specific gene expression as seen in X inactivation and genomic imprinting.

TL;DR: The authors showed that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes in mutant mice that are deficient in DNA methyltransferase activity.

TL;DR: These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histoneacetylation is a targeted phenomenon.