How does DNA methylation repress transcription

TL;DR: L'hyperhomocysteinemie et plusieurs polymorphismes sur les genes du metabolisme des monocarbones sont associes au risque primaire and a the severite of the maladies inflammatoires chroniques de l'intestin (MICI).

TL;DR: It is indicated that the main part of the internal ribosome entry site (IRES) structure of HCV at least is contained in the DNA of the individuals tested.

TL;DR: Morency MJ, Larochelle N, Lochmuller H, Nalbantoglu J, Jani A, Massie B, Karpati G, Holland PC, Stucka R. as discussed by the authors developed dystrophin deletion constructs for gene therapy of Duchenne muscular dystrophy (DMD).

TL;DR: The hypothesis that recombination in maize primari ly occurs i ntragenical ly and that r1 serves as a recombinat ion hot spot in the maize genome is supported.

TL;DR: It is demonstrated that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes in mutant mice that are deficient in DNA methyltransferase activity.

TL;DR: It has become increasingly difficult to hold that reversible promoter methylation is commonly involved in developmental gene control; instead, suppression of parasitic sequence elements appears to be the primary function of cytosine methylation, with crucial secondary roles in allele-specific gene expression as seen in X inactivation and genomic imprinting.

TL;DR: The authors showed that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes in mutant mice that are deficient in DNA methyltransferase activity.

TL;DR: These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histoneacetylation is a targeted phenomenon.