Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy.
TL;DR: Results suggest promising applications for IAA, MHBA, and XN in humans, particularly in the prevention of diet-induced obesity and diabetes.
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Abstract: Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (MHBA) improve health by influencing lipid metabolism, glucose tolerance, and body weight. The modulatory effect of IAA and MHBA on lipid metabolism may also be responsible for a loss in body weight. These results suggest promising applications for IAA, MHBA, and XN in humans, particularly in the prevention of diet-induced obesity and diabetes.
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Citations
Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.).
TL;DR: This review aims to summarize the existing studies focusing on the anticancer activity of xanthohumol and its effects on key signaling molecules and the limitations of current studies and challenges for the clinical use of Xn.
Xanthohumol, a prenylated flavonoid from Hops, exerts anticancer effects against gastric cancer in vitro
TL;DR: Results suggest that Xn exerts anticancer effects against GC via induction of ROS production and subsequent inhibition of NF-κB signaling, and may be a promising candidate treatment against GC progression.
The Multiple Biological Targets of Hops and Bioactive Compounds.
Judy L. Bolton,Tareisha L. Dunlap,Atieh Hajirahimkhan,Obinna Mbachu,Shao-Nong Chen,Luke Chadwick,Dejan Nikolic,Richard B. van Breemen,Guido F. Pauli,Birgit M. Dietz +9 more
TL;DR: Understanding the biological targets of hop dietary supplements and their phytoconstituents will ultimately lead to standardized botanical products with higher efficacy, safety, and chemopreventive properties.
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Effect of Propolis on Diet-Induced Hyperlipidemia and Atherogenic Indices in Mice
Nada Oršolić,Irena Landeka Jurčević,Domagoj Đikić,Dunja Rogić,Dyana Odeh,Vedran Balta,Eleonora Perak Junaković,Svjetlana Terzić,David Jutrić +8 more
TL;DR: The EEP possesses anti-hyperlipidemic and antioxidant activity and exhibits protective action on the cardiovascular system and hepatorenal functions and contributes towards the validation of the traditional use of propolis as a food supplement in aiding hyperlipidemia disorders.
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Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells.
TL;DR: A novel regulating mechanism of redox homeostasis involving with glycolipid metabolism is indicated, and provided a potential candidate for the anti-metastatic therapy of TNBCs.
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