HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia
444
TL;DR: The reduction ofCD11b expression and inhibition of CD11b-dependent monocyte adhesion to endothelium may crucially contribute to the clinical benefit of HMG-CoA reductase inhibitors in CHD, independent of cholesterol-lowering effects.
read more
About: This article is published in Journal of the American College of Cardiology. The article was published on 01 Nov 1997. and is currently open access. The article focuses on the topics: HMG-CoA reductase & Lovastatin.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Drug Design, Development and Therapy
Zhaohui Cai,Anders Bresell,Mark H Steinberg,Debra G Silberg,Stephen T. Furlong +4 more
- 01 Jan 2012
TL;DR: It is possible to predict which patients are at a higher risk of developing liver chemistry signals using pretreatment (baseline) data, and the type of analysis described here could help determine whether new biomarkers offer improved performance over established ones.
Antiatherothrombotic Properties of Statins Implications for Cardiovascular Event Reduction
TL;DR: Experimental animal models suggest that statins may foster stability through a reduction in macrophages and cholesterol ester content and an increase in volume of collagen and smooth muscle cells, which help to explain the early and significant cardiovascular event reduction reported in several clinical trials of statin therapy.
1K
Anti-inflammatory effects of statins: clinical evidence and basic mechanisms.
Mukesh K. Jain,Paul M. Ridker +1 more
TL;DR: Clinical and experimental evidence underlying the anti-inflammatory effects of statins are discussed, suggesting that these medications have potent anti- inflammatory effects that contribute to their beneficial effects in patients.
919
Statins: mechanism of action and effects
Camelia S. Stancu,Anca Sima +1 more
TL;DR: Being the most efficient hypolipidemic compounds that have reduced the rate of mortality in coronary patients, statins reduce significantly the incidence of coronary events, both in primary and secondary prevention.
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation
TL;DR: The effect of statin therapy on immune function, and how this relates to the pathogenesis of autoimmune disease, is reviewed alongside current opinion of what the key biological targets of statins are.
References
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
11.4K
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
7.4K
Regulation of the mevalonate pathway.
TL;DR: The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control, and could be useful in treating certain forms of cancer as well as heart disease.
5.5K
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
J Ames S Hepherd,S Tuart M. C Obbe,I An F Ord,C Hristopher G. I Sles,A. R Oss L Orimer,P Eter W. M Acfarlane,J Ames H. M C K Illop,C Hristopher J. P Ackard,S Tudy G Roup +8 more
- 01 Jan 1995
TL;DR: In this article, a double-blind study was designed to determine whether the administration of pravastatin to men with hypercho-lesterolemia and no history of myocardial infarction correlated with the combined incidence of nonfatal mycardial in-farction and death from coronary heart disease.
3.5K