HIV-1 reverse transcription
Wei-Shau Hu,Stephen H. Hughes +1 more
TL;DR: An overview of reverse transcription is presented, the structure and function of RT are described, some of the cellular and viral factors that can affect reverse transcription are provided, and fidelity and recombination are discussed, two processes in which reverse transcription plays an important role.
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Abstract: Reverse transcription and integration are the defining features of the Retroviridae; the common name "retrovirus" derives from the fact that these viruses use a virally encoded enzyme, reverse transcriptase (RT), to convert their RNA genomes into DNA. Reverse transcription is an essential step in retroviral replication. This article presents an overview of reverse transcription, briefly describes the structure and function of RT, provides an introduction to some of the cellular and viral factors that can affect reverse transcription, and discusses fidelity and recombination, two processes in which reverse transcription plays an important role. In keeping with the theme of the collection, the emphasis is on HIV-1 and HIV-1 RT.
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