Histone Acetylation Regulates Intracellular pH

TL;DR: Targeting cancer-associated metabolic pathways, particularly those involving acetylated amino acids, emerges as an important avenue in the pursuit of combinatorial anticancer strategies and represents a promising new class of inhibitors that could be used alongside traditional chemotherapy agents.

TL;DR: This chapter discusses the brief history and recent advances of chromatin-based processes to provide an overview about the role of Chromatin in development and the deregulation of these processes in diseases.

TL;DR: It is demonstrated that maintenance of NHE1 at a higher level was of critical importance for pluripotency retention in hiPSCs and established a quantitative model of passive β during differentiation.

TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.

TL;DR: A dynamic, finely tuned balance between proton-extruding andProton-importing processes underlies pH homeostasis not only in the cytosol, but in other cellular compartments as well.

TL;DR: It is found that ACL is required for increases in histone acetylation in response to growth factor stimulation and during differentiation, and that glucose availability can affect hist one acetylations in an ACL-dependent manner.

TL;DR: H4-K16Ac inhibits the ability of the adenosine triphosphate–utilizing chromatin assembly and remodeling enzyme ACF to mobilize a mononucleosome, indicating that this single histone modification modulates both higher order chromatin structure and functional interactions between a nonhistone protein and the chromatin fiber.