Histone Acetylation Regulates Intracellular pH
Matthew A. McBrian,Iman Saramipoor Behbahan,Roberto Ferrari,Trent Su,Ta-Wei Huang,Kunwu Li,Candice S. Hong,Heather R. Christofk,Maria Vogelauer,David Seligson,Siavash K. Kurdistani +10 more
TL;DR: A role for histone acetylation of chromatin functions as a rheostat to regulate pH(i) with important implications for mechanism of action and therapeutic use of HDAC inhibitors.
read more
About: This article is published in Molecular Cell. The article was published on 24 Jan 2013. and is currently open access. The article focuses on the topics: Intracellular pH & Acetylation.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Metabolic enzymes function as epigenetic modulators: A Trojan Horse for chromatin regulation and gene expression
TL;DR: In this paper, the authors summarize the recent literature pertinent to metabolic enzymes functioning as epigenetic modulators in the regulation of chromatin architecture and gene expression, and show that almost all the epigenetic modifications require substrates produced by cellular metabolism, and a large proportion of metabolic enzymes can transfer into nucleus to locally produce substrates for epigenetic modification.
2
The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after Exposure to Low‐dose Environmental Chemicals
27 Apr 2022
TL;DR: In this article , a review of recent progress on how low-dose exposure to heavy metal or organic chemicals can lead to epigenetic alterations is presented, and the connections between epigenetic alteration and homeostasis are discussed.
2
A physiological drop in pH decreases mitochondrial respiration, and AMPK and Akt signalling, in L6 myocytes
TL;DR: Exposure to both high and low pH media significantly decreased basal mitochondrial respiration, ATP turnover, and maximum mitochondrial respiratory capacity, which indicates that muscle pH affects several metabolic signalling pathways, including those required for mitochondrial function.
Unveil early-stage nanocytotoxicity by a label-free single cell pH nanoprobe.
Qingbo Yang,Alexandre Cristea,Charles Roberts,Kun Liu,Yang Song,Hai Xiao,Honglan Shi,Yinfa Ma +7 more
TL;DR: The developed novel pH nanoprobe demonstrated a rapid sensing capability at single-cell resolution with minimum invasiveness and may become a promising alternative for a wide range of applications in areas such as single- cell research and precision medicine.
2
References
TopHat: discovering splice junctions with RNA-Seq
TL;DR: The TopHat pipeline is much faster than previous systems, mapping nearly 2.2 million reads per CPU hour, which is sufficient to process an entire RNA-Seq experiment in less than a day on a standard desktop computer.
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
11K
Sensors and regulators of intracellular pH
TL;DR: A dynamic, finely tuned balance between proton-extruding andProton-importing processes underlies pH homeostasis not only in the cytosol, but in other cellular compartments as well.
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
Kathryn E. Wellen,Georgia Hatzivassiliou,Uma M. Sachdeva,Thi Bui,Justin R. Cross,Craig B. Thompson +5 more
TL;DR: It is found that ACL is required for increases in histone acetylation in response to growth factor stimulation and during differentiation, and that glucose availability can affect hist one acetylations in an ACL-dependent manner.
2K
Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
Michael Shogren-Knaak,Haruhiko Ishii,Jian-Min Sun,Michael J. Pazin,James R. Davie,Craig L. Peterson +5 more
TL;DR: H4-K16Ac inhibits the ability of the adenosine triphosphate–utilizing chromatin assembly and remodeling enzyme ACF to mobilize a mononucleosome, indicating that this single histone modification modulates both higher order chromatin structure and functional interactions between a nonhistone protein and the chromatin fiber.
2K