Histone Acetylation Regulates Intracellular pH
Matthew A. McBrian,Iman Saramipoor Behbahan,Roberto Ferrari,Trent Su,Ta-Wei Huang,Kunwu Li,Candice S. Hong,Heather R. Christofk,Maria Vogelauer,David Seligson,Siavash K. Kurdistani +10 more
TL;DR: A role for histone acetylation of chromatin functions as a rheostat to regulate pH(i) with important implications for mechanism of action and therapeutic use of HDAC inhibitors.
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About: This article is published in Molecular Cell. The article was published on 24 Jan 2013. and is currently open access. The article focuses on the topics: Intracellular pH & Acetylation.
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Citations
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.
Kerstin B. Kaufmann,Andy G.X. Zeng,Andy G.X. Zeng,Etienne Coyaud,Laura García-Prat,Efthymia Papalexi,Alex Murison,Estelle M.N. Laurent,Michelle Chan-Seng-Yue,Michelle Chan-Seng-Yue,Olga I. Gan,Kristele Pan,Jessica McLeod,Héléna Boutzen,Sasan Zandi,Sasan Zandi,Shin ichiro Takayanagi,Rahul Satija,Brian Raught,Brian Raught,Stephanie Z. Xie,John E. Dick,John E. Dick +22 more
TL;DR: Dick et al. as discussed by the authors identified distinct subsets of human long-term (LT)-HSCs that responded differently to regeneration-mediated stress: an immune checkpoint ligand CD112lo subset that exhibited a transient engraftment restraint (termed latency) before contributing to hematopoietic reconstitution and a primed CD112hi subset that responded rapidly.
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Novel Approaches for Designing Drugs That Interfere With pH Regulation
TL;DR: Interfering with pH regulation for the treatment of tumors and microbial infections is the main focus of this review, with particular attention paid to inhibitors targeting the above-mentioned proteins.
42
Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology.
TL;DR: How chromatin, by regulating the cellular flux of acetate, may integrate control of cellular physiologic state with gene expression and help explain the observations in cancer tissues is discussed.
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How protons pave the way to aggressive cancers.
Pawel Swietach,Ebbe Boedtkjer,Stine F. Pedersen +2 more
TL;DR: How the pH balance is dysregulated in tumours and how alterations in intracellular and extracellular pH affect tumour biology to accelerate disease progression are discussed, providing a rationale for therapeutic targeting of acid–base disturbances in cancer.
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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
Tsuyoshi Osawa,Teppei Shimamura,Kyoko Saito,Yoko Hasegawa,Naoko Ishii,Miyuki Nishida,Ritsuko Ando,Ayano Kondo,Muyassar Anwar,Rika Tsuchida,Shinjiro Hino,Akihisa Sakamoto,Kaori Igarashi,Kaori Saitoh,Keiko Kato,Keiko Endo,Shotaro Yamano,Yasuharu Kanki,Yoshihiro Matsumura,Takashi Minami,Toshiya Tanaka,Motonobu Anai,Youichiro Wada,Hideki Wanibuchi,Mitsuhiro Hayashi,Akinobu Hamada,Masayuki Yoshida,Shinichi Yachida,Mitsuyoshi Nakao,Juro Sakai,Hiroyuki Aburatani,Masabumi Shibuya,Kentaro Hanada,Satoru Miyano,Tomoyoshi Soga,Tatsuhiko Kodama +35 more
TL;DR: It is shown that glutamine deprivation leads to tumor progression by regulating PE biosynthesis via the ELF3-PCYT2 axis, and manipulating glutamine-responsive genes could be a therapeutic approach to limit cancer progression.
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