Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis

TL;DR: Single molecule epigenomic methods under development are reviewed to overcome limitations, the technical challenges associated with single molecule methods and their potential application to single cells.

TL;DR: A general-purpose genome browser framework ABrowse which provides interactive browsing experience, open data access and collaborative work support, and rich user functions and flexible customization approaches is developed.

TL;DR: In mammals, theDNA methylation is related to different types of cancers and plays the most important role in the placental development and abnormal DNA methylation connected with diseases like cancer, autoimmune diseases, and rheumatoid arthritis.

TL;DR: In this article , the biochemical structure and functions of HM transporter families in plants are systematically summarized, with emphasis on their roles in phytoremediation, and regulatory pathways related to hormones, regulators, and reactive oxygen species (ROS) concerning these transporters are described in detail.

TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.

TL;DR: A genomic sequencing method is reported that provides positive identification of 5-methylcytosine residues and yields strand-specific sequences of individual molecules in genomic DNA, which suggests that the high methylation level of single-copy sequences in sperm may be locally modulated by binding of protein factors in germ-line cells.

TL;DR: Application of an algorithm incorporating all eight characteristics associated with siRNA functionality significantly improves potent siRNA selection and highlights the utility of rational design for selecting potent siRNAs and facilitating functional gene knockdown studies.

TL;DR: The biological significance of 5-methylcytosine was in doubt for many years, but is no longer, and it has become clear that programmed changes in methylation patterns are less important in the regulation of mammalian development than was previously believed.