Journal Article10.7326/0003-4819-131-2-199907200-00002
Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions.
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TL;DR: The hypothesis was that the virologic response to HAART would be substantially worse among unselected patients in an inner-city clinic than among patients enrolled in clinical trials, and this study analyzed data from a cohort of protease inhibitor-naive patients in whom HAART was initiated in the clinic between March 1996 and February 1998.
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Abstract: Unselected patients in whom highly active antiretroviral therapy is started in a clinic setting achieve viral suppression substantially less frequently than do patients in controlled clinical trial...
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Roger Detels,Alvaro Muñoz,Glen McFarlane,Lawrence A. Kingsley,Joseph B. Margolick,Janis V. Giorgi,Lewis K. Schrager,John P. Phair +7 more
TL;DR: In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
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