High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
Liangliang Yang,Sara Pijuan-Galito,Hoon Suk Rho,Aliaksei S Vasilevich,Aysegul Dede Eren,Lu Ge,Pamela Habibovic,Morgan R. Alexander,Jan de Boer,Aurélie Carlier,Patrick van Rijn,Qihui Zhou +11 more
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TL;DR: High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials as mentioned in this paper.
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Abstract: The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development of novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid in the restoration of bodily functions, construct healthy tissues, or regenerate diseased ones. However, the conventional approaches are incapable of screening the huge amount of potential material parameter combinations to identify the optimal cell responses and involve a combination of serendipity and many series of trial-and-error experiments. For advanced tissue engineering and regenerative medicine, highly efficient and complex bioanalysis platforms are expected to explore the complex interaction of cells with biomaterials using combinatorial approaches that offer desired complex microenvironments during healing, development, and homeostasis. In this review, we first introduce materiobiology and its high-throughput screening (HTS). Then we present an in-depth of the recent progress of 2D/3D HTS platforms (i.e., gradient and microarray) in the principle, preparation, screening for materiobiology, and combination with other advanced technologies. The Compendium for Biomaterial Transcriptomics and high content imaging, computational simulations, and their translation toward commercial and clinical uses are highlighted. In the final section, current challenges and future perspectives are discussed. High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials.
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References
A Microfluidic Spheroid Culture Device with a Concentration Gradient Generator for High-Throughput Screening of Drug Efficacy.
Wanyoung Lim,Sungsu Park +1 more
TL;DR: A microfluidic spheroid culture device with a concentration gradient generator (CGG) that enabled cells to form spheroids and grow in the presence of cancer drug gradients is developed that has the potential to become an HTS platform for screening the efficacy of cancer drugs.
Ultrasensitive probing of the protein resistance of PEG surfaces by secondary ion mass spectrometry
Peter Kingshott,Sally L. McArthur,Sally L. McArthur,Helmut Thissen,David G. Castner,Hans J. Griesser,Hans J. Griesser +6 more
TL;DR: The highly sensitive surface analytical techniques X-ray photoelectron spectroscopy and time-of-flight static secondary ion mass spectrometry were used to test the resistance of poly(ethylene glycol) coatings towards adsorption of lysozyme (LYS) and fibronectin (FN).
Alkali‐Mediated Miscibility of Gelatin/Polycaprolactone for Electrospinning Homogeneous Composite Nanofibers for Tissue Scaffolding
Qihui Zhou,Qihui Zhou,Huilan Zhang,Ya Zhou,Zhepao Yu,Huihua Yuan,Huihua Yuan,Bei Feng,Patrick van Rijn,Yanzhong Zhang +9 more
TL;DR: Aqueous sodium hydroxide (NaOH) solution is proposed to modulate the miscibility of a representative natural-synthetic hybrid of gelatin (GT) and polycaprolactone (PCL) for electrospinning homogeneous composite nanofibers to solve the phase separation issue of the synthetic-natural hybrid GT/PCL.