High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
Liangliang Yang,Sara Pijuan-Galito,Hoon Suk Rho,Aliaksei S Vasilevich,Aysegul Dede Eren,Lu Ge,Pamela Habibovic,Morgan R. Alexander,Jan de Boer,Aurélie Carlier,Patrick van Rijn,Qihui Zhou +11 more
117
TL;DR: High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials as mentioned in this paper.
read more
Abstract: The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development of novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid in the restoration of bodily functions, construct healthy tissues, or regenerate diseased ones. However, the conventional approaches are incapable of screening the huge amount of potential material parameter combinations to identify the optimal cell responses and involve a combination of serendipity and many series of trial-and-error experiments. For advanced tissue engineering and regenerative medicine, highly efficient and complex bioanalysis platforms are expected to explore the complex interaction of cells with biomaterials using combinatorial approaches that offer desired complex microenvironments during healing, development, and homeostasis. In this review, we first introduce materiobiology and its high-throughput screening (HTS). Then we present an in-depth of the recent progress of 2D/3D HTS platforms (i.e., gradient and microarray) in the principle, preparation, screening for materiobiology, and combination with other advanced technologies. The Compendium for Biomaterial Transcriptomics and high content imaging, computational simulations, and their translation toward commercial and clinical uses are highlighted. In the final section, current challenges and future perspectives are discussed. High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing.
TL;DR: In this paper , a bio-multifunctional benzaldehyde-terminated 4-arm PEG (4-arm-PEG-CHO)/carboxymethyl chitosan (CMCS)/basic fibroblast growth factor (bFGF) hydrogels (BP/CS-bF GF) are prepared via the dynamic Schiff base reaction for diabetic wound treatment.
162
Recent advances in regenerative biomaterials
Dinglingge Cao,Jiandong Ding +1 more
TL;DR: In this paper , a review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers and bio-derived materials, and highlights the cell-biomaterial interactions.
127
Tuning Water-Resistant Networks in Mussel-Inspired Hydrogels for Robust Wet Tissue and Bioelectronic Adhesion.
TL;DR: Wang et al. as mentioned in this paper used a series of hydrophobic alkyl monomers and adhesive catechol derivatives to systematically develop wet adhesive hydrogels, which were used for continuous monitoring human electrocardiogram (ECG) during swimming and in situ epicardial ECG on a porcine living and beating heart.
91
Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections
Yanjing Ji,Zeyu Han,Han Ding,Xinkai Xu,Danyang Wang,Yanli Zhu,Fei An,Shang Tang,Hui Zhang,Jing Deng,Qihui Zhou +10 more
TL;DR: In this paper, a glucose oxidase (GOx)-modified magnetic nanoparticles (MNPs) were synthesized via a facile and versatile route for investigating their effects on removing PEI-related bacterial/fungal biofilms.
86
Hierarchically hybrid biocoatings on Ti implants for enhanced antibacterial activity and osteogenesis.
TL;DR: In this paper, hierarchical hybrid biocoatings on Ti implants are developed by gradual incorporation of polydopamine (PDA), ZnO nanoparticles (nZnO), and chitosan (CS)/nanocrystal hydroxyapatite (nHA) via oxidative self-polymerization, nanoparticle deposition, solvent casting and evaporation methods for enhancing their antibacterial activity and osteogenesis.
81
References
Local force and geometry sensing regulate cell functions.
Viola Vogel,Michael P. Sheetz +1 more
TL;DR: Tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms of eukaryotic cells.
2.3K
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Kiichi Watanabe,Morio Ueno,Daisuke Kamiya,Ayaka Nishiyama,Michiru Matsumura,Takafumi Wataya,Jun Takahashi,Satomi Nishikawa,Shin-Ichi Nishikawa,Keiko Muguruma,Yoshiki Sasai +10 more
TL;DR: Application of a selective Rho-associated kinase (ROCK) inhibitor, Y-27632, to hES cells markedly diminishes dissociation-induced apoptosis, increases cloning efficiency and facilitates subcloning after gene transfer, and enables SFEB-cultured hES Cells to survive and differentiate into Bf1+ cortical and basal telencephalic progenitors.
2.3K
Fluorescence Lifetime Measurements and Biological Imaging
TL;DR: The lifetime of a photophysical process is the time required by a population of N electronically excited molecules to be reduced by a factor of e via the loss of energy through fluorescence and other non-radiative processes and the average length of time τ is called the mean lifetime, or simply lifetime.
A new type of synthetic peptide library for identifying ligand-binding activity
Kit S. Lam,Sydney E. Salmon,Evan M. Hersh,Victor J. Hruby,Wieslaw M. Kazmierski,Richard J. Knapp +5 more
TL;DR: The simple methodology greatly enhances the production and rapid evaluation of random libraries of millions of peptides so that acceptor-binding ligands of high affinity can be rapidly identified and sequenced, on the basis of a "one-bead, one-peptide9 approach.
2.1K
Tackling the widespread and critical impact of batch effects in high-throughput data
Jeffrey T. Leek,Robert B. Scharpf,Héctor Corrada Bravo,Héctor Corrada Bravo,David M. Simcha,Benjamin Langmead,W. Evan Johnson,Donald Geman,Keith A. Baggerly,Rafael A. Irizarry +9 more
TL;DR: It is argued that batch effects (as well as other technical and biological artefacts) are widespread and critical to address and experimental and computational approaches for doing so are reviewed.