Journal Article10.1002/JBM.A.30320
High surface energy enhances cell response to titanium substrate microstructure.
Ge Zhao,Zvi Schwartz,Marco Wieland,Frank Rupp,Jürgen Geis-Gerstorfer,David L. Cochran,Barbara D. Boyan +6 more
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TL;DR: Osteoblasts grown on modified Ti surfaces exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1 and 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy.
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Abstract: Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO2 surfaces that have a complex microtopography increase bone-to-implant contact and removal torque forces in vivo and induce osteoblast differentiation in vitro. Studies examining osteoblast response to controlled surface chemistries indicate that hydrophilic surfaces are osteogenic, but TiO2 surfaces produced until now exhibit low surface energy because of adsorbed hydrocarbons and carbonates from the ambient atmosphere or roughness induced hydrophobicity. Novel hydroxylated/hydrated Ti surfaces were used to retain high surface energy of TiO2. Osteoblasts grown on this modified surface exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1. Moreover, 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy. This suggests that increased bone formation observed on modified Ti surfaces in vivo is due in part to stimulatory effects of high surface energy on osteoblasts.
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Citations
Impact of Dental Implant Surface Modifications on Osseointegration.
Ralf Smeets,PD Bernd Stadlinger,Frank Schwarz,Benedicta Beck-Broichsitter,Ole Jung,Clarissa Precht,Frank Kloss,Alexander Gröbe,Max Heiland,Tobias Ebker +9 more
TL;DR: This paper provides a comprehensive overview of surface modifications that beneficially alter the topography, hydrophilicity, and outer coating of dental implants in order to enhance osseointegration in healthy as well as in compromised bone.
Titanium surface characteristics, including topography and wettability, alter macrophage activation
Kelly M. Hotchkiss,Gireesh B. Reddy,Sharon L. Hyzy,Zvi Schwartz,Barbara D. Boyan,Rene Olivares-Navarrete +5 more
TL;DR: It is demonstrated that macrophages cultured on high surface wettability materials produce an anti-inflammatory microenvironment, and this property may be used to improve the healing response to biomaterials.
587
Effects of implant surface coatings and composition on bone integration: a systematic review.
TL;DR: The review of the experimental surface alterations revealed that thin calcium phosphate (CaP) coating technology can solve the problems associated with thick CaP coatings, while they still improve implant bone integration compared with non-coated titanium implants.
567
The effect of ultraviolet functionalization of titanium on integration with bone
Hideki Aita,Norio Hori,Masato Takeuchi,Takeo Suzuki,Masahiro Yamada,Masakazu Anpo,Takahiro Ogawa +6 more
TL;DR: The data indicated that UV light pretreatment of titanium substantially enhances its osteoconductive capacity, in association with UV-catalytic progressive removal of hydrocarbons from the TiO2 surface, suggesting a photofunctionalization of titanium enabling more rapid and complete establishment of bone-titanium integration.
498
Requirement for both micron-and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topography
TL;DR: The results demonstrate a synergistic effect between high surface energy and topography of Ti substrates and show that both micron-scale and submicron scale structural features are necessary.
482
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TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
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Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength
TL;DR: In this article, the effect of surface roughness of hydroxyapatite (HA) on human bone marrow cell response was investigated using a rotating disc device that applied a linear range of shear stresses to the cells.
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Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption.
Despina D. Deligianni,N Katsala,Spyridon Ladas,D. Sotiropoulou,Joëlle Amédée,Yannis F. Missirlis +5 more
TL;DR: Cell attachment and proliferation were surface roughness sensitive and increased as the roughness of Ti alloy increased, and may be explained by the differential adsorption of the two proteins onto smooth and rough Ti alloy surfaces.
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