Journal Article10.1002/JBM.A.30320
High surface energy enhances cell response to titanium substrate microstructure.
Ge Zhao,Zvi Schwartz,Marco Wieland,Frank Rupp,Jürgen Geis-Gerstorfer,David L. Cochran,Barbara D. Boyan +6 more
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TL;DR: Osteoblasts grown on modified Ti surfaces exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1 and 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy.
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Abstract: Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO2 surfaces that have a complex microtopography increase bone-to-implant contact and removal torque forces in vivo and induce osteoblast differentiation in vitro. Studies examining osteoblast response to controlled surface chemistries indicate that hydrophilic surfaces are osteogenic, but TiO2 surfaces produced until now exhibit low surface energy because of adsorbed hydrocarbons and carbonates from the ambient atmosphere or roughness induced hydrophobicity. Novel hydroxylated/hydrated Ti surfaces were used to retain high surface energy of TiO2. Osteoblasts grown on this modified surface exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1. Moreover, 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy. This suggests that increased bone formation observed on modified Ti surfaces in vivo is due in part to stimulatory effects of high surface energy on osteoblasts.
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Citations
Inverse response of osteoblasts and fibroblasts to growth on carbon-deposited titanium surfaces.
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Implantes dentários com superfície tratada: revisão de literatura
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TL;DR: In this article, a review of the different surface types of dental implants correlating them with osseointegration rate, chemical composition and surface roughness of titanium is presented, showing that both roughness and chemical surface treatment can greatly influence the shear surface strength.
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