Journal Article10.1016/j.carbpol.2022.119253
High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases.
Ruilian Li,Limeng Zhu,Dongdong Li,Wenjing Wang,Chen Zhang,Siming Jiao,Jinhua Wei,Lishi Ren,Yuchen Zhang,Xun Gou,Xiang-Hua Yuan,Yuguang Du,Zhuo Wang +12 more
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TL;DR: In this paper , the authors used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains.
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About: This article is published in Carbohydrate Polymers. The article was published on 01 Feb 2022. The article focuses on the topics: Medicine & Polysaccharide.
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Citations
Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review.
Eman M. Khalaf,Noor Adil Abood,Raghad Z Atta,Andrés Alexis Ramírez-Coronel,Reem S. Alazragi,Rosario Mireya Rome Parra,Osama H Abed,Munther Abosaooda,Abduladheem Turki Jalil,Yasser Fakri Mustafa,Asghar Narmani,Bagher Farhood +11 more
TL;DR: The potential properties of chitosan nanoparticles, such as biocompatibility, biodegradability, serum stability, solubility, non-immunogenicity, anti-inflammatory properties, appropriate pharmacokinetics and pharmacodynamics, and so forth, have made them excellent candidates for biomedical applications as discussed by the authors .
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Chitosan and Chitosan Nanoparticles: Parameters Enhancing Antifungal Activity
TL;DR: In this paper , a review on how the chitosan parameters: molecular weight, degree of deacetylation, acetylation pattern and dispersity of these features shape its antifungal activity.
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Tuning chitosan's chemical structure for enhanced biological functions.
Mortaza Aghbashlo,Hamid Amiri,S. Masoud Moosavi Basri,Hajar Rastegari,Su Shiung Lam,Junting Pan,Vijai Kumar Gupta,Meisam Tabatabaei +7 more
TL;DR: In this article , a review of emerging enzymes and cell factories for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the acetylation pattern and structural modification of chITosan to tune its functions.
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Natural antimicrobial oligosaccharides in the food industry.
Xuewu Liu,Xingfei Li,Yuxiang Bai,Xing Zhou,Long Chen,Chao Qiu,Cheng Lu,Zhengyu Jin,Jie Long,Zheng Jun Xie +9 more
TL;DR: In this article , the authors present a review on the antimicrobial activity of different oligosaccharides and their possible mechanisms of action with respect to their direct and indirect effects, as well as the extended applications of oligosACcharides from the food source industry to food processing are discussed.
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Synthesis of acylated derivatives of chitosan oligosaccharide and evaluation of their potential antifungal agents on Fusarium oxysporum.
Bing Li,Lingyu Han,Jinlong Ma,Mei-Shan Zhao,Bing-Luen Yang,Mei Xu,Yu Gao,Qingsong Xu,Yuguang Du +8 more
TL;DR: In this paper , the authors synthesized chitosan oligosaccharide (COS) derivatives by grafting acyl chlorides of different alkyl chain lengths onto COS molecules and further investigated their physicochemical properties and antimicrobial activity.
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References
A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR
Arnab Chakraborty,Liyanage D. Fernando,Wenxia Fang,Malitha C. Dickwella Widanage,Pingzhen Wei,Cheng Jin,Thierry Fontaine,Jean-Paul Latgé,Tuo Wang +8 more
TL;DR: In this paper, the cell wall structure of a fungal pathogen Aspergillus fumigatus and four mutants depleted of major structural polysaccharides was compared.
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Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis
Rajendra Upadhya,Lorina G. Baker,Woei C. Lam,Charles A. Specht,Maureen J. Donlin,Jennifer K. Lodge +5 more
TL;DR: Chitin is an essential component of the cell wall of Cryptococcus neoformans conferring structural rigidity and integrity under diverse environmental conditions and further implicates chitosan as being a critical factor for the pathogenesis of C. neo formans.
Activity of Sanguinarine against Candida albicans Biofilms.
Hua Zhong,Dan Dan Hu,Gan Hai Hu,Gan Hai Hu,Juan Su,Shuang Bi,Zhuo Er Zhang,Zheng Wang,Ri Li Zhang,Zheng Xu,Yuan Ying Jiang,Yan Wang +11 more
TL;DR: The results show that SAN exhibits strong activity against C. albicans biofilms, and the activity was associated with its inhibitory effect on adhesion and hypha formation due to cAMP pathway suppression.
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Effect of the molecular weight of chitosan on its antifungal activity against Candida spp. in planktonic cells and biofilm
Lana Glerieide Silva Garcia,Glaucia Morgana de Melo Guedes,Maria Lucilene Queiroz da Silva,Débora de Souza Collares Maia Castelo-Branco,José Júlio Costa Sidrim,Rossana de Aguiar Cordeiro,Marcos Fábio Gadelha Rocha,Rodrigo Silveira Vieira,Raimunda Sâmia Nogueira Brilhante +8 more
TL;DR: The aim of this study was to determine the effects of molecular weight (MW) of chitosan on Candida albicans, Candida tropicalis and Candida parapsilosis sensu stricto and the formation of biofilms.
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PHR1, a pH-regulated gene of Candida albicans encoding a glucan-remodelling enzyme, is required for adhesion and invasion.
TL;DR: Results suggest that PHR1 is not required for the induction of hyphal development but plays a key role in the maintenance of hypha growth, and the beta-(1,3)-glucan processing catalysed by Phr1p is of fundamental importance in thetenance of the morphological state on which the adhesive and invasive properties of C. albicans greatly depend.