Journal Article10.1016/j.carbpol.2022.119253
High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases.
Ruilian Li,Limeng Zhu,Dongdong Li,Wenjing Wang,Chen Zhang,Siming Jiao,Jinhua Wei,Lishi Ren,Yuchen Zhang,Xun Gou,Xiang-Hua Yuan,Yuguang Du,Zhuo Wang +12 more
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TL;DR: In this paper , the authors used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains.
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About: This article is published in Carbohydrate Polymers. The article was published on 01 Feb 2022. The article focuses on the topics: Medicine & Polysaccharide.
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Citations
Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review.
Eman M. Khalaf,Noor Adil Abood,Raghad Z Atta,Andrés Alexis Ramírez-Coronel,Reem S. Alazragi,Rosario Mireya Rome Parra,Osama H Abed,Munther Abosaooda,Abduladheem Turki Jalil,Yasser Fakri Mustafa,Asghar Narmani,Bagher Farhood +11 more
TL;DR: The potential properties of chitosan nanoparticles, such as biocompatibility, biodegradability, serum stability, solubility, non-immunogenicity, anti-inflammatory properties, appropriate pharmacokinetics and pharmacodynamics, and so forth, have made them excellent candidates for biomedical applications as discussed by the authors .
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Chitosan and Chitosan Nanoparticles: Parameters Enhancing Antifungal Activity
TL;DR: In this paper , a review on how the chitosan parameters: molecular weight, degree of deacetylation, acetylation pattern and dispersity of these features shape its antifungal activity.
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Tuning chitosan's chemical structure for enhanced biological functions.
Mortaza Aghbashlo,Hamid Amiri,S. Masoud Moosavi Basri,Hajar Rastegari,Su Shiung Lam,Junting Pan,Vijai Kumar Gupta,Meisam Tabatabaei +7 more
TL;DR: In this article , a review of emerging enzymes and cell factories for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the acetylation pattern and structural modification of chITosan to tune its functions.
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Natural antimicrobial oligosaccharides in the food industry.
Xuewu Liu,Xingfei Li,Yuxiang Bai,Xing Zhou,Long Chen,Chao Qiu,Cheng Lu,Zhengyu Jin,Jie Long,Zheng Jun Xie +9 more
TL;DR: In this article , the authors present a review on the antimicrobial activity of different oligosaccharides and their possible mechanisms of action with respect to their direct and indirect effects, as well as the extended applications of oligosACcharides from the food source industry to food processing are discussed.
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Synthesis of acylated derivatives of chitosan oligosaccharide and evaluation of their potential antifungal agents on Fusarium oxysporum.
Bing Li,Lingyu Han,Jinlong Ma,Mei-Shan Zhao,Bing-Luen Yang,Mei Xu,Yu Gao,Qingsong Xu,Yuguang Du +8 more
TL;DR: In this paper , the authors synthesized chitosan oligosaccharide (COS) derivatives by grafting acyl chlorides of different alkyl chain lengths onto COS molecules and further investigated their physicochemical properties and antimicrobial activity.
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References
Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans.
TL;DR: It is demonstrated chitosan is necessary for virulence and persistence in the mammalian host in Cryptococcus neoformans.
The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall.
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TL;DR: The β-(1,3)-glucan branching mechanism is unravels, a phenomenon occurring during construction of the cell wall which is essential for fungal life and suggests that enzymes involved in the glucan branching could be exploited as antifungal targets.
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TL;DR: In a batch-feeding system the production of antibiotically active nikkomycins could be increased up to 3 g dm−3 and the selective production of single compounds was possible by feeding precursors or using mutants of Streptomyces tendae.
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Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall
TL;DR: The results suggest that Chs8p synthesized the long‐chitin microfibrils, and Chs3p synthesizes the short‐ch itin rodlets at the same cellular location, which suggests the architecture of the chitin skeleton of C.’albicans is shaped by the action of more than one chit in synthase at the site of cell wall synthesis.
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The role of the cell wall in fungal pathogenesis
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