Journal Article10.1016/j.carbpol.2022.119253
High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases.
Ruilian Li,Limeng Zhu,Dongdong Li,Wenjing Wang,Chen Zhang,Siming Jiao,Jinhua Wei,Lishi Ren,Yuchen Zhang,Xun Gou,Xiang-Hua Yuan,Yuguang Du,Zhuo Wang +12 more
16
TL;DR: In this paper , the authors used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains.
read more
About: This article is published in Carbohydrate Polymers. The article was published on 01 Feb 2022. The article focuses on the topics: Medicine & Polysaccharide.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review.
Eman M. Khalaf,Noor Adil Abood,Raghad Z Atta,Andrés Alexis Ramírez-Coronel,Reem S. Alazragi,Rosario Mireya Rome Parra,Osama H Abed,Munther Abosaooda,Abduladheem Turki Jalil,Yasser Fakri Mustafa,Asghar Narmani,Bagher Farhood +11 more
TL;DR: The potential properties of chitosan nanoparticles, such as biocompatibility, biodegradability, serum stability, solubility, non-immunogenicity, anti-inflammatory properties, appropriate pharmacokinetics and pharmacodynamics, and so forth, have made them excellent candidates for biomedical applications as discussed by the authors .
81
Chitosan and Chitosan Nanoparticles: Parameters Enhancing Antifungal Activity
TL;DR: In this paper , a review on how the chitosan parameters: molecular weight, degree of deacetylation, acetylation pattern and dispersity of these features shape its antifungal activity.
48
Tuning chitosan's chemical structure for enhanced biological functions.
Mortaza Aghbashlo,Hamid Amiri,S. Masoud Moosavi Basri,Hajar Rastegari,Su Shiung Lam,Junting Pan,Vijai Kumar Gupta,Meisam Tabatabaei +7 more
TL;DR: In this article , a review of emerging enzymes and cell factories for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the acetylation pattern and structural modification of chITosan to tune its functions.
43
Natural antimicrobial oligosaccharides in the food industry.
Xuewu Liu,Xingfei Li,Yuxiang Bai,Xing Zhou,Long Chen,Chao Qiu,Cheng Lu,Zhengyu Jin,Jie Long,Zheng Jun Xie +9 more
TL;DR: In this article , the authors present a review on the antimicrobial activity of different oligosaccharides and their possible mechanisms of action with respect to their direct and indirect effects, as well as the extended applications of oligosACcharides from the food source industry to food processing are discussed.
24
Synthesis of acylated derivatives of chitosan oligosaccharide and evaluation of their potential antifungal agents on Fusarium oxysporum.
Bing Li,Lingyu Han,Jinlong Ma,Mei-Shan Zhao,Bing-Luen Yang,Mei Xu,Yu Gao,Qingsong Xu,Yuguang Du +8 more
TL;DR: In this paper , the authors synthesized chitosan oligosaccharide (COS) derivatives by grafting acyl chlorides of different alkyl chain lengths onto COS molecules and further investigated their physicochemical properties and antimicrobial activity.
16
References
Chitosan oligosaccharide (COS): An overview
Muhammad Naveed,Lucas Phil,Muhammad Sohail,Muhammad Hasnat,Mirza Muhammad Faran Ashraf Baig,Awais Ullah Ihsan,Muhammad Shumzaid,Mohib Ullah Kakar,Tahir Mehmood Khan,M D Akabar,Muhammad Imtiaz Hussain,Qi-Gang Zhou +11 more
TL;DR: COS is shown to have higher cellular transduction and completely absorbable via intestinal epithelium due to its cationic sphere exposed on the more exposed shorter N-glucosamine (N-Glc) units.
404
Glycosylphosphatidylinositol-anchored Glucanosyltransferases Play an Active Role in the Biosynthesis of the Fungal Cell Wall
Isabelle Mouyna,Thierry Fontaine,Marina Vai,Michel Monod,William A. Fonzi,M. Diaquin,Laura Popolo,Robbert P. Hartland,Jean-Paul Latgé +8 more
TL;DR: The results show that transglycosidases anchored to the plasma membrane via glycosylphosphatidylinositols can play an active role in fungal cell wall synthesis.
369
Chitosan, the Deacetylated Form of Chitin, Is Necessary for Cell Wall Integrity in Cryptococcus neoformans
TL;DR: Utilizing a collection of chitin/polysaccharide deacetylase deletion strains, it is determined that during vegetative growth, chitosan helps to maintain cell integrity and aids in bud separation.
368
A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens
Meirong Song,Yuan Liu,Yuan Liu,Xiaoyong Huang,Shuangyang Ding,Yang Wang,Jianzhong Shen,Kui Zhu +7 more
TL;DR: Antibiotic adjuvant peptide SLAP-S25 binds to the inner and outer membranes of Gram-negative bacteria to cause membrane damage and boost efficacy of all major antibiotic classes.
351
Tasting the fungal cell wall.
TL;DR: A comprehensive understanding of the interactions between the host membrane receptors and the fungal cell wall components is still lacking and thefungal adhesins playing a role in adhesion to host have been only explored in yeasts.
306