High Mobility Group Protein 1 and Dickkopf-Related Protein 1 in Schizophrenia and Treatment-Resistant Schizophrenia: Associations With Interleukin-6, Symptom Domains, and Neurocognitive Impairments.
Arafat Hussein Al-Dujaili,Rana Fadhil Mousa,Hussein Kadhem Al-Hakeim,Michael Maes,Michael Maes,Michael Maes +5 more
51
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Neuroinflammation in Schizophrenia: The Key Role of the WNT/β-Catenin Pathway
TL;DR: This research’s triptych could be a novel therapeutic approach to counteract both neuroinflammation and oxidative stress in schizophrenia.
81
CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.
Mariya Ivanovska,Zakee Abdi,Marianna Murdjeva,Danielle Silveira Macêdo,Danielle Silveira Macêdo,Annabel Maes,Michael Maes,Michael Maes,Michael Maes +8 more
TL;DR: Increased CCL-11 production during inflammatory conditions may play a role in human disease including age-related cognitive decline, schizophrenia, mood disorders and neurodegenerative disorders, and a new drug target in the treatment and prevention of those disorders.
69
In schizophrenia, immune-inflammatory pathways are strongly associated with depressive and anxiety symptoms, which are part of a latent trait which comprises neurocognitive impairments and schizophrenia symptoms.
Abbas F. Almulla,Khalid F. Al-Rawi,Michael Maes,Michael Maes,Michael Maes,Hussein Kadhem Al-Hakeim +5 more
TL;DR: Immune-inflammatory and EOS pathways contribute to the phenome of schizophrenia, which comprises OSOS, affective, and physiosomatic symptoms, and G-CoDe, which is strongly associated with a latent vector extracted from all symptoms.
37
The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines.
Tomasz Boczek,Joanna Mackiewicz,Marta Sobolczyk,Julia Wawrzyniak,Malwina Lisek,Bozena Ferenc,Feng Guo,Ludmila Zylinska +7 more
TL;DR: In this article, the authors reviewed and synthesized the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology and found that GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca2+ mobilization.
34
First Episode Psychosis and Schizophrenia Are Systemic Neuro-Immune Disorders Triggered by a Biotic Stimulus in Individuals with Reduced Immune Regulation and Neuroprotection.
Michael Maes,Michael Maes,Michael Maes,Kitiporn Plaimas,Apichat Suratanee,Cristiano Noto,Buranee Kanchanatawan +6 more
TL;DR: In this paper, the characteristics of the protein-protein interaction (PPI) network of antipsychotic-naive first episode psychosis (AN-FEP) and schizophrenia (FES) patients are established.
31
References
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
32.8K
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
TL;DR: Review of five studies involving the PANSS provided evidence of its criterion-related validity with antecedent, genealogical, and concurrent measures, its predictive validity, its drug sensitivity, and its utility for both typological and dimensional assessment.
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
11K