High affinity RNA ligands of basic fibroblast growth factor

TL;DR: In this paper, the authors present methods for identifying nucleic acid ligands of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate Mixture of NAs, in which the NAs have different affinities for the target molecule.

TL;DR: In this article, materials and methods for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PD GF receptor, VEGF, and VEGFs receptor or any combination thereof with great affinity and specificity are provided.

TL;DR: In this paper, a method for diagnosing transmissible spongiform encephalopathy disease in a subject is described. But the method is based on the results of the contacting step.

TL;DR: The SELEX (Systematic Evolution of Ligands by EXponential Enrichment) method as discussed by the authors was proposed for the identification of nucleic acid ligands, where a candidate mixture of single stranded nucleic acids having regions of randomized sequence is contacted with a target compound and those nucleic amino acids having an increased affinity to the target are partitioned from the remainder of the candidate mixture.

TL;DR: The Systematic Evolution of Ligands by Exponential enrichment (SELEX) method as mentioned in this paper was proposed to identify the ligand components of the nucleic acid antibodies by the method of the invention referred to as SELEX, wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic amino acid and amplified for further partitioning.

TL;DR: In this paper, the authors proposed a method for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins, such as HIV, herpes virus, papillomavirus and other infections.

TL;DR: In this article, high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissues targets, and the methods for obtaining such ligands are described.