Journal Article10.1080/10426500802111207
Heteroaromatization with Sulfonamido Phenyl Ethanone, Part I: Synthesis of Novel Pyrrolo[2,3-D]Pyrimidine and Pyrrolo[3,2-E][1,2,4]Triazolo[1,5-C]Pyrimidine Derivatives Containing Dimethylsulfonamide Moiety
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TL;DR: In this paper, 4-(5-Amino-4-cyano-1-p-tolyl-1H-pyrrol-3-yl)-N,N-dimethyl-benzenesulfonamide derivatives were converted to several pyrrolo[2,3-d]pyrimidin-5-yl]-pyrimidine derivatives (5,7,9, and 13).
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Abstract: 4-(5-Amino-4-cyano-1-p-tolyl-1H-pyrrol-3-yl)-N,N-dimethyl-benzenesulfonamide (4) was prepared and converted to several pyrrolo[2,3-d]pyrimidin-5-yl)-N,N-dimethyl-benzenesulfonamide derivatives (5,7,9, and 13). Cyclocondensation of 13 with different electrophilic carbon reagents afforded several 4-(N,N-dimethylaminosulfonylphenyl)]pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]-pyrimidine derivatives (14–17,19, and 20); IR, 1HNMR, and mass spectra of the newly synthesized compounds were recorded. Most of the obtained compounds were screened against Gram-positive and Gram-negative bacteria and fungi, for which some of these derivatives gave promising results.
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Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives.
TL;DR: A variety of novel 1,2-dihydropyridines 10-17, thiophenes 18-21 and thiazole 22 having a biologically active sulfone moiety were obtained via the reaction of 2-cyano-N'-[1-(4-(piperidin-1-ylsulfonyl) phenyl) ethylidene] acetohydrazide 3 with a variety of reagents.
172
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties
TL;DR: Among the tested derivatives, compounds 16, 18 and 20-24 showed potent activity as inhibitors for the tumor associated transmembrane isoforms (hCA IX and XII) in the nanomolar and subnanomolar range, with high selectivity.
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Novel N-sulfonylphthalimides: Efficient synthesis, X-ray characterization, spectral investigations, POM analyses, DFT computations and antibacterial activity
Ismahene Grib,Malika Berredjem,Khadidja Otmane Rachedi,Seif-Eddine Djouad,Sofiane Bouacida,Rania Bahadi,Tan-Sothea Ouk,Mekki Kadri,Taibi Ben Hadda,Billel Belhani +9 more
TL;DR: In this paper, N-sulfonylphthalimides were synthesized in good yields by condensation of anhydride phthalic with various sulfonamides by two different methods: conventional synthesis and immersion ultrasonic assisted method, in one step.
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Design, synthesis and anticancer activity of some novel thioureido-benzenesulfonamides incorporated biologically active moieties.
TL;DR: Compounds 3, 6, 8, 9, 10, 15 and 16 may represent good candidates for further biological investigations as anticancer agents and their cytotoxic activity could be due to their action as MK-2 enzyme inhibitors.
Heteroaromatization with Sulfonamido Phenyl Ethanone, Part II: Synthesis of Novel Thiazolyl Acetonitriles and Thiazolyl Acrylonitriles and Their Derivatives Containing Dimethylsulfonamide Moiety
TL;DR: In this article, pyrazolo[5,1-c][1,2,4]triazine derivatives were converted to pyrazolimitrile derivatives through reactions with a variety of organic electrophiles and nucleophiles.
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