Herb Robert’s Gift against Human Diseases: Anticancer and Antimicrobial Activity of Geranium robertianum L.
Łukasz Świątek,Inga Wasilewska,Anastazja Boguszewska,Agnieszka Grzegorczyk,Jakub Rezmer,Barbara Rajtar,Małgorzata Polz-Dacewicz,Elwira Sieniawska +7 more
TL;DR: In this paper , the phytochemical profile of extracts from aerial parts of G. robertianum, commercially available in Poland and to study their anticancer potential and antimicrobial properties, including the antiviral, antibacterial, and antifungal effects.
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Abstract: Geranium robertianum L. is a widely distributed plant used as a traditional herbal medicine, but the knowledge of its biological properties still needs to be improved. Thus, the purpose of this presented research was to assess the phytochemical profile of extracts from aerial parts of G. robertianum, commercially available in Poland and to study their anticancer potential and antimicrobial properties, including the antiviral, antibacterial, and antifungal effects. Additionally, the bioactivity of fractions obtained from the hexane and ethyl acetate extract was analyzed. The phytochemical analysis revealed the presence of organic and phenolic acids, hydrolysable tannins (gallo- and ellagitannins), and flavonoids. Significant anticancer activity was found for G. robertianum hexane extract (GrH) and ethyl acetate extract (GrEA) with an SI (selectivity index) between 2.02 and 4.39. GrH and GrEA inhibited the development of HHV-1-induced cytopathic effect (CPE) in virus-infected cells and decreased the viral load by 0.52 log and 1.42 log, respectively. Among the analyzed fractions, only those obtained from GrEA showed the ability to decrease the CPE and reduce the viral load. The extracts and fractions from G. robertianum showed a versatile effect on the panel of bacteria and fungi. The highest activity was observed for fraction GrEA4 against Gram-positive bacteria, including Micrococcus luteus ATCC 10240 (MIC 8 μg/mL), Staphylococcus epidermidis ATCC 12228 (MIC 16 μg/mL), Staphylococcus aureus ATCC 43300 (MIC 125 μg/mL), Enterococcus faecalis ATCC 29212 (MIC 125 μg/mL), and Bacillus subtilis ATCC 6633 (MIC 125 μg/mL). The observed antibacterial effect may justify the traditional use of G. robertianum to treat hard-to-heal wounds.
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Citations
Evaluating Phytochemical Profiles, Cytotoxicity, Antiviral Activity, Antioxidant Potential, and Enzyme Inhibition of Vepris boiviniana Extracts
Kassim Bakar,Nilofar,Andilyat Mohamed,Łukasz Świątek,Benita Hryć,Elwira Sieniawska,Barbara Rajtar,Claudio Ferrante,Luigi Menghini,Gokhan Zengin,Małgorzata Polz-Dacewicz +10 more
TL;DR: The research underscores the diverse bioactive properties of Vepris boiviniana extracts, exhibiting potent antioxidant, enzyme inhibitory, and cytotoxicity potential against cancer cells.
4
Anthelminthic and antimicrobial effects of hedge woundwort (Stachys sylvatica L.) growing in Southern Kazakhstan
Aigerim Z. Mukhamedsadykova,Martyna Kasela,Kaldanay Kozhanova,Zuriyadda Sakipova,Wirginia Kukula-Koch,Aleksandra Józefczyk,Łukasz Świątek,Barbara Rajtar,Magdalena Iwan,Przemysław Kołodziej,Agnieszka Ludwiczuk,Gulnara Kadyrbayeva,Gulnur N. Kuntubek,A. S. Mamatova,Anna Bogucka-Kocka,Anna Malm +15 more
TL;DR: The hydroethanolic extract of Stachys sylvatica L. exhibits anthelminthic, antimicrobial, and antiviral activities.
A comprehensive study on Geranium robertianum L. antibacterial potential.
M. Stanković,Petar Ristivojević,Đurđa Ivković,Milena G Milutinović,Jelena Terzić,Olgica D. Stefanović +5 more
TL;DR: The findings of this study indicate that the extracts of G. robertianum can be considered as potential natural antibacterial agents in the control of microorganisms.
Exploring medicinal plant diversity in Serra da Estrela Natural Park (Portugal): An ethnobotanical study (Part I)
Radhia Aitfella Lahlou,Filomena Carvalho,Maria João Pereira,João Lopes,Luís R Silva +4 more
Polyphenols Investigation and In Vitro Antioxidant Capacity of Romanian Wild-Grown Geranium spp. (Geraniaceae)
Cornelia BEJENARU,Adina-Elena SEGNEANU,Andrei BIŢĂ,Ludovic Everard Bejenaru,Marilena-Viorica Hovaneţ,Maria Viorica Ciocîlteu,Adriana Cosmina Tîrnă,Antonia Blendea,George Dan Mogoşanu,Cornelia BEJENARU,Adina-Elena SEGNEANU,Andrei BIŢĂ,Ludovic Everard Bejenaru,Marilena-Viorica Hovaneţ,Maria Viorica Ciocîlteu,Adriana Cosmina Tîrnă,Antonia Blendea,George Dan Mogoşanu +17 more
Abstract: Geranium spp. are recognized as rich sources of phenolic metabolites, with potential health benefits, yet comparative evaluations remain limited. We assessed four wild-grown Geranium spp. (G. dissectum—G1, G. lucidum—G2, G. pusillum—G3, and G. robertianum—G4), from southwestern Romanian flora, using complementary antioxidant (DPPH, ABTS, and FRAP) and phytochemical (TPC and TFC) assays. Targeted UHPLC/UV with MS confirmation quantified eight phenolic acids. FRAP provided the strongest discrimination between species, and mirrored TPC, with the highest values in G4 sample. ABTS and DPPH supported the same ranking, and TFC varied only modestly, but differences were narrower and not significant between species. Caffeic acid was highest in G1 sample, and chlorogenic acid was selectively elevated in G3 sample. Gallic and protocatechuic acids were highest in G4 sample, both tracking the FRAP/TPC gradient. Syringic acid and vanillic acid were enriched in weaker antioxidant species. Distinctive signatures included high p-coumaric acid in G4 sample and chlorogenic and ferulic acids in G3 sample. Antioxidant potential among Geranium spp. is best explained by TPC, particularly hydroxybenzoic acids, with FRAP emerging as the most sensitive discriminator. These findings provide a comparative benchmark for Geranium spp. phytochemistry and a framework for future pharmacological studies.
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