Hepcidin in non-alcoholic fatty liver disease regulated by the TLR4/NF-κB signaling pathway
TL;DR: The abnormal activation of the TLR4/NF-κB signaling pathway may cause non-alcoholic fatty liver disease through the overexpression of Hepcidin through the activation of toll-like receptor 4/nuclear factor (NF)-κB signal pathway.
read more
Abstract: The aim of our study was to analyze the role of toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signal pathway on Hepcidin regulation in non-alcoholic fatty liver disease (NAFLD). A total of 60 male Sprague-Dawley rats were randomly divided into the control, NAFLD and intervention groups. Rats in the control group were fed with standard laboratory diet, and rats in the NAFLD and intervention groups were fed with a high-fat diet. A final volume of 2 ml of pathenolide (10 µmol/l) was administered intraperitoneally only to the rats in the intervention group. The tissue sections were stained with hematoxylin and eosin and the pathological changes in liver tissues were observed and scored. The levels of TLR4 and NF-κB in liver tissues were quantified by western blotting. NAFLD rats appeared to have typical liver fatty degeneration and the expression of TLR4/NF-κB proteins and Hepcidin mRNA was significantly higher than that in the control group (P<0.05). However, the pathological changes observed in the intervention group had a marked improvement with a significant reduction in the TLR4/NF-κB protein and Hepcidin mRNA expression (P<0.05). In conclusion, the abnormal activation of the TLR4/NF-κB signaling pathway may cause NAFLD through the overexpression of Hepcidin.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Antioxidative, inflammatory and immune responses in hydrogen peroxide-induced liver injury of tilapia (GIFT, Oreochromis niloticus).
Rui Jia,Jinliang Du,Liping Cao,Yao Li,Opigo Johnson,Zhengyan Gu,Galina Jeney,Pao Xu,Guojun Yin +8 more
TL;DR: Overall results suggested that H2O2 hepatotoxicity was mainly concerned with lipid peroxidation, impairment antioxidant defense systems, inflammatory response and immunotoxicity, and Nrf2/Keap1 and NF-κB signaling pathways played important roles in oxidative stress-induced liver injury in fish.
62
Nutrition and Liver Disease.
TL;DR: This Editorial comments the articles appearing in this special issue of Nutrients, “Nutrition and Liver disease” dealing with multiple diagnostic and therapeutic features that relate the outcomes of liver disease to nutrition.
38
miR-182-5p Attenuates High-Fat -Diet-Induced Nonalcoholic Steatohepatitis in Mice
TL;DR: In this article, the role of miR-182-5p in TLR4 expression and high-fat-diet (HFD)-induced NASH in vitro and in vivo was investigated.
27
Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis
TL;DR: It is demonstrated that renal hepcidin synthesis protects the DN against hemin and hemoglobin-mediated injury and prevents necroptosis.
Protective Effect of Fuzi Lizhong Decoction against Non-alcoholic Fatty Liver Disease via Anti-inflammatory Response through Regulating p53 and PPARG Signaling.
Jia-Yao Yang,Wei Ma,Qunchao Mei,Juefei Song,Lei Shu,Shu Zhang,Chenyu Li,Liu An,Nianlong Du,Zhao-Hong Shi +9 more
TL;DR: It was shown that FLD significantly improved NAFLD by regulating the immune system to induce the release of interleukin-10 (IL-10), interferon-α (IFN-α), and IFN-β through activating p53 signaling and inhibiting PPARG signaling in vivo and in vitro.
14
References
Cellular and molecular mechanisms of fibrosis.
TL;DR: Current understanding of the cellular and molecular mechanisms of fibrogenesis is explored and components of the renin–angiotensin–aldosterone system (ANG II) have been identified as important regulators of fibrosis and are being investigated as potential targets of antifibrotic drugs.
Nonalcoholic Fatty Liver Disease: A Systematic Review
TL;DR: How to identify patients with nonalcoholic fatty liver disease at greatest risk of non Alcoholic steatohepatitis and cirrhosis is illustrated and the role and limitations of current diagnostics and liver biopsy are discussed to provide an outline for the management of patients across the spectrum of non alcoholic fatty Liver disease.
2.1K
Hepcidin and iron regulation, 10 years later
TL;DR: Modulation of hepcidin and ferroportin expression during infection and inflammation couples iron metabolism to host defense and decreases iron availability to invading pathogens.
973
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis.
Chantal A. Rivera,Patrick Adegboyega,Nico van Rooijen,Arlene Tagalicud,Monique Allman,Matthew Wallace +5 more
TL;DR: In this paper, the authors examined the relationship between hepatic TLR-4 expression and Kupffer cell content during the genesis of steatohepatitis in male C57BL/6 and C3H/HouJ mice.
690
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
TL;DR: It is shown that saturated FAs represent an endogenous danger in the form of a first hit, up‐regulate the inflammasome in NASH, and induce sensitization to a second hit with LPS for IL‐β release in hepatocytes, and for the first time that inflammaome activation occurs in isolated hepatocytes in steatohepatitis.
636