Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Federico Bussolino,M. F. Di Renzo,Marina Ziche,E Bocchietto,Martina Olivero,Luigi Naldini,Giovanni Gaudino,Luca Tamagnone,A Coffer,Paolo M. Comoglio +9 more
TL;DR: Data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate and lacks activities related to hemostasis-thrombosis, inflammation and endothelium cells accessory functions.
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Abstract: Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by the MET protooncogene Endothelial cells express the MET gene and expose at the cell surface the mature protein (p190MET) made of a 50 kD (alpha) subunit disulfide linked to a 145-kD (beta) subunit HGF binding to endothelial cells identifies two sites with different affinities The higher affinity binding site (Kd = 035 nM) corresponds to the p190MET receptor Sub-nanomolar concentrations of HGF, but not of a recombinant inactive precursor, stimulate the receptor kinase activity, cell proliferation and motility HGF induces repairs of a wound in endothelial cell monolayer HGF stimulates the scatter of endothelial cells grown on three-dimensional collagen gels, inducing an elongated phenotype In the rabbit cornea, highly purified HGF promotes neovascularization at sub-nanomolar concentrations HGF lacks activities related to hemostasis-thrombosis, inflammation and endothelial cells accessory functions These data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate
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Angiogenesis-Based Strategy by Hepatocyte Growth Factor for the Treatment of Ischemic Organ Diseases: From Biology to Clinical Trials
Shinya Mizuno
- 01 Jan 2017
TL;DR: A therapeutic potential of HGF will be discussed, with a focus on biological mechanisms and preclinical or clinical outcomes during ischemic organ diseases.
2
Evaluating vandetanib in the treatment of medullary thyroid cancer: patient-reported outcomes
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TL;DR: Vandetanib is approved by the FDA and EMA for symptomatic or progressive MTC in patients with unresectable locally advanced or metastatic disease in adults, adolescents, and children older than 5 years, as it has been shown to improve progression-free survival.
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endothelial cell activation by Axl tyrosine kinase receptor mediated - Inhibition of vascular endothelial growth factor receptor 2
Carlo Avanzi,Federico Bussolino,Margherita Gallicchio,Stefania Mitola,Donatella Valdembri,Roberto Fantozzi,Brian Varnum +6 more
- 01 Jan 2013
TL;DR: This article discusses Signal Transduction, Hemostasis, Thrombosis, and Vascular Biology, and Cell Adhesion and Motility, and articles on similar topics can be found in the following Blood collections.
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Angiogenesis Models Identify Factors Which Regulate Endothelial Cell Differentiation
Derrick S. Grant,David Morales,Maria C. Cid,Hynda K. Kleinman +3 more
- 01 Jan 1994
TL;DR: During development, blood vessels are rapidly formed from angioblasts in the mesoderm, followed by extensive branching of the vessels to supply the needs of the growing tissue, in the adult, vessels form a complex and stable network providing a transit-way for blood cells, oxygen, growth factors, hormones, etc., to all tissues.
2
Physiological Roles and Therapeutic Implications of Hepatocyte Growth Factor for Angiogenesis
Hiroyuki Ohnishi,Shinya Mizuno,Kiyomasa Oka,Toshikazu Nakamura +3 more
- 01 Jan 2013
TL;DR: The concept that amount of HGF may determine the predisposition to ischemic disease, healthy conditions, or neoplastic disease, all of which depend on the degree of c-Met activation, and in part, concomitant angiogenic activity is provided.
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