Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Federico Bussolino,M. F. Di Renzo,Marina Ziche,E Bocchietto,Martina Olivero,Luigi Naldini,Giovanni Gaudino,Luca Tamagnone,A Coffer,Paolo M. Comoglio +9 more
TL;DR: Data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate and lacks activities related to hemostasis-thrombosis, inflammation and endothelium cells accessory functions.
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Abstract: Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by the MET protooncogene Endothelial cells express the MET gene and expose at the cell surface the mature protein (p190MET) made of a 50 kD (alpha) subunit disulfide linked to a 145-kD (beta) subunit HGF binding to endothelial cells identifies two sites with different affinities The higher affinity binding site (Kd = 035 nM) corresponds to the p190MET receptor Sub-nanomolar concentrations of HGF, but not of a recombinant inactive precursor, stimulate the receptor kinase activity, cell proliferation and motility HGF induces repairs of a wound in endothelial cell monolayer HGF stimulates the scatter of endothelial cells grown on three-dimensional collagen gels, inducing an elongated phenotype In the rabbit cornea, highly purified HGF promotes neovascularization at sub-nanomolar concentrations HGF lacks activities related to hemostasis-thrombosis, inflammation and endothelial cells accessory functions These data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate
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Citations
Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans.
Tomoko Sugiura,Saki Takahashi,Kazusa Sano,Tetsushi Abe,Kazuhiro Fukuta,Kiichi Adachi,Toshikazu Nakamura,Kunio Matsumoto,Noritaka Nakamichi,Yukio Kato +9 more
TL;DR: The plasma concentration profile in mice with glycerol-induced acute renal failure was similar to that in normal mice, indicating a minimal contribution of kidney to systemic clearance of HGF, and accumulation of fluorescein-4-isocyanate-labeled HGF in renal tubules in both cases suggests the occurrence of efficient endocytosis of H GF in kidney.
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Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study
Zhaoqi Yuan,Zhu Zhu,Fangxing Zhu,Feixue Ding,Yinmin Wang,Xiuxia Wang,Xusong Luo,Jun Yang,Fei Liu,Di Sun +9 more
TL;DR: It is demonstrated that ADSCs can enhance different malignant properties of DFSP cells in vitro, which should not be neglected when considering the clinical use of human ADSCs and its related derivatives in skin regenerative therapies.
Effect of hepatocyte growth factor on endogenous hepatocarcinogenesis in rats fed a choline-deficient L-amino acid-defined diet
Chihiro Nakanishi,Akihiro Moriuchi,Akio Ido,Masatsugu Numata,Ildeok Kim,Kazunori Kusumoto,Satoru Hasuike,Hiroo Abe,Kenji Nagata,Yutaka Akiyama,Hirofumi Uto,Hiroaki Kataoka,Hirohito Tsubouchi +12 more
TL;DR: Results indicate that long-term administration of rh-HGF does not accelerate hepatocarcinogenesis in rats fed a CDAA diet, and do not completely exclude the potential of HGF-induced hepatocARCinogenesis; this issue must be resolved before rh- HGF can be used for patients with intractable liver diseases, especially those with cirrhosis.
•Journal Article
The role of circulating angiogenic factors in patients operated on for localized malignant melanoma.
Åsa Bolander,Gunnar Wagenius,Anders Larsson,Daniel Brattström,Gustav J. Ullenhag,Patrik Hesselius,Simon Ekman,Michael Bergqvist +7 more
TL;DR: Investigating circulating levels of the angiogenic factors, VEGF-A and -D, their receptors 1-3 and hepatocyte growth factor (HGF)/scatter factor, in patients shortly after primary surgery for localized malignant melanoma indicates that production of these angiogenesis factors may be due to sources other than malign melanoma cells.
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The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis.
TL;DR: It is concluded that Grb2 does not contribute to the 'presentation' of CrkII to p(145betaMET) and is likely to induce cell proliferation partly via the Ras/mitogen-activated protein kinase route.
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