Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Federico Bussolino,M. F. Di Renzo,Marina Ziche,E Bocchietto,Martina Olivero,Luigi Naldini,Giovanni Gaudino,Luca Tamagnone,A Coffer,Paolo M. Comoglio +9 more
TL;DR: Data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate and lacks activities related to hemostasis-thrombosis, inflammation and endothelium cells accessory functions.
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Abstract: Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by the MET protooncogene Endothelial cells express the MET gene and expose at the cell surface the mature protein (p190MET) made of a 50 kD (alpha) subunit disulfide linked to a 145-kD (beta) subunit HGF binding to endothelial cells identifies two sites with different affinities The higher affinity binding site (Kd = 035 nM) corresponds to the p190MET receptor Sub-nanomolar concentrations of HGF, but not of a recombinant inactive precursor, stimulate the receptor kinase activity, cell proliferation and motility HGF induces repairs of a wound in endothelial cell monolayer HGF stimulates the scatter of endothelial cells grown on three-dimensional collagen gels, inducing an elongated phenotype In the rabbit cornea, highly purified HGF promotes neovascularization at sub-nanomolar concentrations HGF lacks activities related to hemostasis-thrombosis, inflammation and endothelial cells accessory functions These data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate
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