Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Federico Bussolino,M. F. Di Renzo,Marina Ziche,E Bocchietto,Martina Olivero,Luigi Naldini,Giovanni Gaudino,Luca Tamagnone,A Coffer,Paolo M. Comoglio +9 more
TL;DR: Data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate and lacks activities related to hemostasis-thrombosis, inflammation and endothelium cells accessory functions.
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Abstract: Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by the MET protooncogene Endothelial cells express the MET gene and expose at the cell surface the mature protein (p190MET) made of a 50 kD (alpha) subunit disulfide linked to a 145-kD (beta) subunit HGF binding to endothelial cells identifies two sites with different affinities The higher affinity binding site (Kd = 035 nM) corresponds to the p190MET receptor Sub-nanomolar concentrations of HGF, but not of a recombinant inactive precursor, stimulate the receptor kinase activity, cell proliferation and motility HGF induces repairs of a wound in endothelial cell monolayer HGF stimulates the scatter of endothelial cells grown on three-dimensional collagen gels, inducing an elongated phenotype In the rabbit cornea, highly purified HGF promotes neovascularization at sub-nanomolar concentrations HGF lacks activities related to hemostasis-thrombosis, inflammation and endothelial cells accessory functions These data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate
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The safety and efficacy of vandetanib in the treatment of progressive medullary thyroid cancer.
Poupak Fallahi,Silvia Martina Ferrari,Enke Baldini,Marco Biricotti,Salvatore Ulisse,Gabriele Materazzi,Paolo Miccoli,Alessandro Antonelli +7 more
TL;DR: In patients with aggressive differentiated thyroid cancer, vandetanib has shown promising results, and further research is needed to determine the ideal targeted therapy, based on tumor molecular characterization and host factors, to obtain the best response in terms of survival and quality of life.
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Non-paralleled increase of hepatocyte growth factor and vascular endothelial growth factor in the eyes with angiogenic and nonangiogenic fibroproliferation.
TL;DR: Focal increases in HGF on fibroproliferation in the eye regardless of the involvement of angiogenesis were not in remarkable relation with angiogenic activity, unlike VEGF, which suggested a more extensive role of HGF than V EGF strictly related toAngiogenesis.
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Variation in innate immunity genes and risk of multiple myeloma.
Mark P. Purdue,Qing Lan,Idan Menashe,Tongzhang Zheng,Yawei Zhang,Meredith Yeager,Meredith Yeager,H. Dean Hosgood,Shelia Hoar Zahm,Stephen J. Chanock,Stephen J. Chanock,Nathaniel Rothman,Dalsu Baris +12 more
TL;DR: The findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies.
Hepatocyte growth factor is upregulated by low-density lipoproteins and inhibits endothelin-1 release.
Cornelia Haug,Alexandra Schmid-Kotsas,Ulrike Zorn,Max G. Bachem,Sabine Schuett,Adolf Gruenert,Eva Rozdzinski +6 more
TL;DR: The LDL-induced upregulation of HGF synthesis in HCAEC and the inhibitory effect of H GF on ET-1 synthesis suggest a protective role of HGI in coronary atherosclerosis.
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Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor (scatter factor/hepatocyte growth factor receptor).
Masayuki Komada,Naomi Kitamura +1 more
TL;DR: The low level of kinase activity and the lack of biological activity of the mutant receptor indicate that the major autophosphorylation site positively regulates the tyrosine kinase of the c-Met receptor and phosphorylation of cellular substrates in the scatter factor/hepatocyte growth factor signaling pathway.
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