Journal Article10.1016/J.JHEP.2009.01.019
Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: A meta-analysis
TL;DR: This meta-analysis suggests that HCV genotype 1b plays an important role in HCC development, especially in patients with early stage liver disease.
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About: This article is published in Journal of Hepatology. The article was published on 01 Jun 2009. The article focuses on the topics: Risk factor & Hepatitis C.
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Citations
MicroRNAs: Role in Hepatitis C Virus pathogenesis.
TL;DR: There is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver disease.
83
Liver injury and disease pathogenesis in chronic hepatitis C.
TL;DR: In vitro studies have begun to reveal molecular mechanisms responsible for virus-induced changes in cell metabolism and cellular kinase cascades that culminate in pathologic consequences in the liver, such as steatosis, insulin resistance, and carcinogenesis, and how these findings may be relevant to disease pathogenesis in patients are discussed.
78
Hepatitis C virus infection, microRNA and liver disease progression
TL;DR: This review focuses on recent studies enforcing the contribution of miRNAs in HCV life cycle and coordinated regulation inHCV mediated liver disease progression.
73
Clinical and epidemiological features of hepatitis C virus infection in South Korea: A prospective, multicenter cohort study
Mun Hyuk Seong,Ho Kil,Young Seok Kim,Si Hyun Bae,Youn Jae Lee,Han Chu Lee,Byunghak Kang,Sook Hyang Jeong +7 more
TL;DR: Age, intravenous drug use, needle stick injury, transfusion before 1995, and tattoos were the independent risk factors of HCV infection.
69
Hepatitis C virus infection and risk of stroke: a systematic review and meta-analysis.
TL;DR: This meta-analysis suggested that HCV infection increased the risk of stroke, and more prospective cohort studies will be needed to confirm this association with underlying biological mechanisms in the future.
References
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
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Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C
John G. McHutchison,Stuart C. Gordon,Eugene R. Schiff,Mitchell L. Shiffman,William M. Lee,Vinod K. Rustgi,Zachary Goodman,Mei Hsiu Ling,Susannah Cort,Janice K. Albrecht +9 more
TL;DR: In patients with chronic hepatitis C, initial therapy withinterferon and ribavirin was more effective than treatment with interferon alone.