Journal Article10.1016/J.LEUKRES.2007.12.001
Hemangioblast does exist.
27
TL;DR: The simultaneously spatial and temporal emergence of ndothelial cells and hematopoietic cells in the yolk sac blood slands led to the hypothesis that they were derived from a ommon precursor, the hemangioblast.
read more
About: This article is published in Leukemia Research. The article was published on 01 Jun 2008. The article focuses on the topics: Hemangioblast & Yolk sac.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 - Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome.
Mariusz Z. Ratajczak,Kamila Bujko,Andrzej K Ciechanowicz,Kasia Sielatycka,Monika Cymer,Wojciech Marlicz,Magda Kucia,Magda Kucia +7 more
TL;DR: There is a possibility that human VSELs residing in adult tissues could be damaged by SARS-CoV-2, with remote effects on tissue/organ regeneration, and the data indicates that Ang 1–7 may have a protective effect.
Vascular wall resident progenitor cells: A review
TL;DR: This review gives an overview of adult large vessel progenitors established in the vascular wall during embryogenesis and their role in the maintenance of wall homeostasis.
78
The role of progenitor cells in the development of intimal hyperplasia.
TL;DR: It appears that progenitor cells do indeed contribute to intimal hyperplasia, at least in mouse models of arterial injury, and the need for a more in-depth understanding of the mechanisms underlying progenitors cell recruitment is needed.
51
Myelofibrosis with myeloid metaplasia : The advanced phase of an untreated disseminated hematological cancer Time to change our therapeutic attitude with early upfront treatment?
TL;DR: Normalisation of elevated blood cell counts in the early phase of the "chronic myeloproliferative syndromes" - ET and PV - should be the therapeutic target in the future using alpha-interferon as monotherapy or in combination with conventional (hydroxyurea and anagrelide) and novel agents (JAK2-inhibitors).
45
Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands
Toshiyuki Tsunoda,Yasuo Takashima,Yoko Tanaka,Takahiro Fujimoto,Keiko Doi,Yumiko Hirose,Midori Koyanagi,Yasuhiro Yoshida,Tadashi Okamura,Masahide Kuroki,Takehiko Sasazuki,Senji Shirasawa +11 more
TL;DR: It is shown that Zfat-deficient (Zfat−/−) mice are embryonic-lethal, with impaired differentiation of hematopoietic progenitor cells in blood islands, where ZFAT is exactly expressed and functions as a critical transcription factor for primitive hematoiesis through direct-regulation of Tal1, Lmo2, and Gata1.
42
References
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
4.2K
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
TL;DR: The in vitro developmental potential of mouse blastocyst-derived embryonic stem cell lines and the consistency with which the cells express this potential are presented as aspects which open up new approaches to the investigation of embryogenesis.
2.2K
Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.
TL;DR: This paper used hybridoma monoclonal antibodies obtained after immunization of mice with rat cells to study rat cell-surface antigens present on subpopulations of rat lymphocytes.
2K
AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis
TL;DR: The results suggest that AML1-regulated target genes are essential for definitive hematopoiesis of all lineages, and that this defect was intrinsic to the stem cells in that AMl1-/-ES cells failed to contribute to hematocerosis in chimeric animals.
2K
A common precursor for hematopoietic and endothelial cells
TL;DR: Findings provide strong evidence that the blast colony-forming cell represents the long-hypothesized hemangioblast, the common precursor of the hematopoietic and endothelial lineages.