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Handbook of Solubility Data for Pharmaceuticals
Abolghasem Jouyban
- 26 Aug 2009
TL;DR: The literature on solubility data for pharmaceuticals has changed in recent years from being mainly concerned with liquid chromatography to gas chromatography and now also includes “solid-phase” data.
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Abstract: Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز
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Citations
Mathematical derivation of the Jouyban-Acree model to represent solute solubility data in mixed solvents at various temperatures
TL;DR: The combined nearly ideal binary solvent/Redlich-Kister model and its extended version, i.e. the Jouyban-Acree model, are the most common models in the solubility prediction area as mentioned in this paper.
284
Ionic liquids as a potential tool for drug delivery systems
TL;DR: The efforts made in using ILs in drug solubility, API formulation and drug delivery, including topical, transdermal and oral delivery, are presented, with particular emphasis on recent developments.
250
Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures
Sahel Vahdati,Ali Shayanfar,Jalal Hanaee,Jalal Hanaee,Fleming Martínez,William E. Acree,Abolghasem Jouyban +6 more
TL;DR: In this paper, the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures was investigated and the results showed that carvedilols are solubile in both types of mixtures.
Thermodynamic analysis of the solubility of ketoprofen in some propylene glycol + water cosolvent mixtures
TL;DR: In this article, the van't Hoff and Gibbs equations were used to evaluate the solubility of ketoprofen in propylene glycol+water (PG+W) cosolvent mixtures.
172
References
Solubility of Organic Solutes in Ethanol/Water Mixtures
An Li,Samuel H. Yalkowsky +1 more
TL;DR: It is found that the extent of solubilization strongly depends on the solute hydrophobicity and the ethanol concentration in the solvent mixture, and patterns of deviation from the log-linear model are related to the structure and hydrophobia of the solutes.
97
Towards an understanding of the molecular mechanism of solvation of drug molecules: A thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin
TL;DR: Temperature dependencies of saturated vapor pressure for the monoclinic modification of paracetamol, acetanilide, and phenacetin were measured and thermodynamic functions of sublimation calculated and analysis of packing energies based on geometry optimization of molecules in the crystal lattices using diffraction data and the program Dmol3 was carried out.
94
Prediction of aqueous solubility and partition coefficient optimized by a genetic algorithm based descriptor selection method.
Jörg K. Wegner,Andreas Zell +1 more
TL;DR: A fast and flexible descriptor selection method using a genetic algorithm variant (GA-SEC) and an artificial neural network model to predict the aqueous solubility logS and the octanol/water partition coefficient logP.
89
Solubility prediction of paracetamol in binary and ternary solvent mixtures using Jouyban-Acree model.
TL;DR: The Jouyban-Acree model has been used to predict thesolubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures based on model constants computed using a minimum number of solubility data of the solute in water/ethanol/propylene/ethylene binary mixtures.
80
Aqueous solubility prediction of environmentally important chemicals from the mobile order thermodynamics
Paul Ruelle,Ulrich W. Kesselring +1 more
TL;DR: In this paper, the aqueous solubility of only sligthly polar compounds with no hydrogen bond donor capacity was predicted with an average absolute error of 0.37 log units.
79