Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study
John Penders,Carel Thijs,Piet A. van den Brandt,Ischa Kummeling,Bianca E. P. Snijders,Foekje Stelma,Hanne Adams,Ronald van Ree,Ellen E. Stobberingh +8 more
TL;DR: In this article, Gut microbiota composition in early infancy and the subsequent development of atopic manifestations and sensitisation was examined, and the presence of Escherichia coli was associated with a higher risk of developing eczema (OR adj ǫ= 1.87; 95% CI 1.15 to 3.04).
read more
Abstract: Background and aims: Perturbations in intestinal microbiota composition due to lifestyle changes may be involved in the development of atopic diseases. We examined gut microbiota composition in early infancy and the subsequent development of atopic manifestations and sensitisation. Methods: The faeces of 957 infants aged 1 month and participating in the KOALA Birth Cohort Study were analysed using quantitative real-time PCR. Information on atopic symptoms (eczema, wheeze) and potential confounders was acquired through repeated questionnaires. Total and specific IgE were measured in venous blood samples collected during home visits when the infant was 2 years old. During these home visits a clinical diagnosis of atopic dermatitis was made according to the UK-Working Party criteria. Results: The presence of Escherichia coli was associated with a higher risk of developing eczema (OR adj = 1.87; 95% CI 1.15 to 3.04), this risk being increased with increasing numbers of E coli (p for trend = 0.016). Infants colonised with Clostridium difficile were at higher risk of developing eczema (OR adj = 1.40; 95% CI 1.02 to 1.91), recurrent wheeze (OR adj = 1.75; 95% CI 1.09 to 2.80) and allergic sensitisation (OR adj = 1.54; 95% CI 1.02 to 2.31). Furthermore, the presence of C difficile was also associated with a higher risk of a diagnosis of atopic dermatitis during the home visit (OR adj = 1.73; 95% CI 1.08 to 2.78). Conclusion: This study demonstrates that differences in gut microbiota composition precede the development of atopy. Since E coli was only associated with eczema and C difficile was associated with all atopic outcomes, the underlying mechanisms explaining these association may be different.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The gut microbiota shapes intestinal immune responses during health and disease
TL;DR: Findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut are discussed, and the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms is raised.
4.7K
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
3.2K
The role of the gut microbiota in nutrition and health
TL;DR: The complex interplay between the gut microbiota, diet and health is considered and better definition of those dominant commensal bacteria, community profiles and system characteristics that produce stable gut communities beneficial to health is important.
2.8K
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
Christian Milani,Sabrina Duranti,Francesca Bottacini,Eoghan Casey,Francesca Turroni,Jennifer Mahony,Clara Belzer,Susana Delgado Palacio,Silvia Arboleya Montes,Leonardo Mancabelli,Gabriele Andrea Lugli,Juan M. Rodríguez,Lars Bode,Willem M. de Vos,Willem M. de Vos,Miguel Gueimonde,Abelardo Margolles,Douwe van Sinderen,Marco Ventura +18 more
TL;DR: The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed.
1.5K
The composition of the gut microbiota throughout life, with an emphasis on early life.
Juan M. Rodríguez,Kiera Murphy,Catherine Stanton,R. Paul Ross,Olivia I. Kober,Nathalie Juge,Ekaterina Avershina,Knut Rudi,Arjan Narbad,Maria C. Jenmalm,Julian Marchesi,Maria Carmen Collado +11 more
TL;DR: A review discusses recent studies on the early colonization and factors influencing this process which impact on health and an adequate establishment of microbiota and its maintenance throughout life would reduce the risk of disease in early and late life.
1.2K
References
Microbes, immunoregulation, and the gut
TL;DR: Two distinct, but rapidly converging, areas of research have emphasised the need to understand, and ultimately to manipulate, the authors' physiological interactions with commensal flora, and with other transient but harmless organisms from the environment that affect immunoregulatory circuits.
370
Microflora‐associated characteristics in faeces from allergic and nonallergic infants
TL;DR: In this paper, the authors compared the gut microbial flora in 25 allergic and 47 non-allergic 13-month-old infants (range 11-18), through analysing microflora-associated biochemical markers in faeces.
268
Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease.
Pirkka V. Kirjavainen,Effie Apostolou,Taina Arvola,Seppo Salminen,Glenn R. Gibson,Erika Isolauri +5 more
TL;DR: The most prominent question raised by these data is whether Gram-positive bacteria may have distinctive importance in protection against atopic sensitization.
190
Dietary n-3 and n-6 fatty acids alter avian metabolism: metabolism and abdominal fat deposition
R. E. Newman,Wayne L. Bryden,E. Fleck,J. R. Ashes,William A. Buttemer,Leonard H Storlien,J. A. Downing +6 more
TL;DR: It is indicated that dietary fatty acid profile influences nutrient partitioning in broiler chickens and lowers plasma concentrations of serum triacylglycerols and cholesterol.
Analysis of the intestinal microflora: a renaissance
TL;DR: The ability of microbial ecologists to analyse the composition of complex bacterial communities has been greatly enhanced by the application of molecular methodologies and should enable an accurate record of the identity and population dynamics of the inhabitants of the intestinal tract to be obtained, which will lead to a new concept of the intestine microflora of humans.
165